New Aspects on Modulation Of Sympathetic Neurotransmission: by Change of Probability of Secretion of Single Mixed Quanta From Two Classes of Nerve Varicosities

Stjärne, L.; Tanaka, Etsuro; Århem, Peter

doi:10.1007/978-3-642-73160-0_10

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…stimulus-evoked release inside or outside the electrode, is in agreement with observations in the guinea-pig vas deferens (Brock & Cunnane 1987. Thus, the regenerative mechanism providing the high safety factor for conduction presumably resides in voltage-gated Na+ channels in the varicosities (Cunnane & Stjarne 1984b, Beattie et al 1986, Stjarne et a/. 1988b.…”

Section: Discussionmentioning

confidence: 99%

Some pharmacological applications of an extracellular recording method to study secretion of a sympathetic co‐transmitter, presumably ATP

Stjärne

1989

Acta Physiologica Scandinavica

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Extracellular recording in guinea-pig or mouse vas deferens or rat tail artery was used to study the effects of some pharmacological agents on the nerve terminal spike (NTS) and the secretion of a sympathetic co-transmitter (presumably ATP), as reflected in the excitatory junction current (EJC). A negative-going EJCi (i for inside) was assumed to reflect release from sites inside, and a positive-going EJCo (o for outside) release from sites outside the recording electrode. Passage into or out of the electrode seemed to be slow. Tetrodotoxin (TTX) in the outer medium blocked the NTS and ECJo as well as EJCi; TTX in the pipette blocked stimulus-evoked but not spontaneous EJCi. The dihydropyridine Ca2+ channel blocking agent, nifedipine, was without effect, but Cd2+ in the external medium blocked EJCo and also, by an effect apparently 'upstream' of varicosities, inhibited EJCi (i.e. release within the patch) but not the NTS. When present in the outer medium the alpha 2-adrenoceptor agonists, clonidine and xylazine, blocked both EJCo and EJCi, but not the NTS. The effects of clonidine were blocked by yohimbine, which in itself increased the EJCo by about 50%. Neuropeptide Y and met-enkephalin in the outer medium blocked EJCo; the effect of met-enkephalin was blocked by naloxone. The K+ channel blocking agents, tetraethylammonium and 4-aminopyridine, inside or outside the electrode, increased dramatically the size of EJCi or EJCo, respectively.

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Section: Discussionmentioning

confidence: 99%

Some pharmacological applications of an extracellular recording method to study secretion of a sympathetic co‐transmitter, presumably ATP

Stjärne

1989

Acta Physiologica Scandinavica

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Basic mechanisms and local modulation of nerve impulse-induced secretion of neurotransmitters from individual sympathetic nerve varicosities

Stjärne

Reviews of Physiology, Biochemistry and Pharmacology

157

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Electrically evoked noradrenaline release in the rat hypothalamic paraventricular nucleus studied by in vivo electrochemistry: Autoregulation by alpha-2 receptors

1990

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New Aspects on Modulation Of Sympathetic Neurotransmission: by Change of Probability of Secretion of Single Mixed Quanta From Two Classes of Nerve Varicosities

Cited by 3 publications

References 53 publications

Some pharmacological applications of an extracellular recording method to study secretion of a sympathetic co‐transmitter, presumably ATP

Some pharmacological applications of an extracellular recording method to study secretion of a sympathetic co‐transmitter, presumably ATP

Basic mechanisms and local modulation of nerve impulse-induced secretion of neurotransmitters from individual sympathetic nerve varicosities

Electrically evoked noradrenaline release in the rat hypothalamic paraventricular nucleus studied by in vivo electrochemistry: Autoregulation by alpha-2 receptors

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