New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development

Moreno, Juan J.

doi:10.1016/j.bcp.2008.07.033

Cited by 143 publications

(92 citation statements)

References 94 publications

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“…Besides, the eicosanoids produced by the 20-carbon PUFA oxidation can be esterified in the cellular membrane with phospholipids, where they can be stored and also carry out different biological activities (Hammond and O'Donnell 2012). The HETE studied in this work are among such products, which can be generated by both nonenzymatic oxidation, as well as by the enzymatic activity of the lipoxygenases and CYP proteins (11-HETE) (Moreno 2009). On the other hand, HETE may modulate the cellular cycle, inhibiting the apoptosis and being either mitogenic agents in different cellular types (Moreno 2009).…”

Section: Discussionmentioning

confidence: 97%

“…The HETE studied in this work are among such products, which can be generated by both nonenzymatic oxidation, as well as by the enzymatic activity of the lipoxygenases and CYP proteins (11-HETE) (Moreno 2009). On the other hand, HETE may modulate the cellular cycle, inhibiting the apoptosis and being either mitogenic agents in different cellular types (Moreno 2009). This suggests that they alone (or the products derived from their metabolism) may be involved in different cellular processes, such as differentiation.…”

Section: Discussionmentioning

confidence: 99%

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Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

et al. 2013

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Metabolites derived from the polyunsaturated fatty acids (PUFA) may modulate the mesenchymal stromal cell (MSC) differentiation. Such cells can differentiate into different cellular types, including adipocytes and osteoblasts. Aging favors the bone marrow MSC differentiation toward the former, causing a loss of bone density associated with pathologies like osteoporosis. The omega-6 arachidonic acid (AA) favors MSC adipogenesis to a greater extent than omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In this work, we study the joint action of both PUFA. Thus, not induced and induced to adipocyte or osteoblast MSC were treated with 20 lM of each PUFA (either AA, AA ? DHA or AA ? EPA). The expression of osteogenic and adipogenic molecular markers, the alox15b lipoxygenase gene expression and the 5-, 8-, 11-, 12-and 15-hydroxyeicosatetraenoic acids (HETE) derived from the AA metabolism in the culture media were determined. The results show that the adipogenesis induction of AA is not suppressed by the joint presence of EPA and DHA. In fact, both increased the adipogenic effect of AA on MSC differentiated into osteoblasts. The different HETE concentrations increased in cultures supplemented with AA, albeit such concentrations were lower in the cultures induced to differentiate, mainly at day 21 after the induction. Furthermore, the reduction in the HETE concentration was correlated with a higher expression of the alox15b gene. These results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

et al. 2013

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“…There is little information about HETE/EET production by intestinal epithelial cells or the effect of these eicosanoids on intestinal epithelial growth, although many recent Page 10 of 35 A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 10 papers have focused on the emerging effects of HETEs on cell signaling and physiological/pathological cell growth [36]. Given that 5-LOX [14], 12-LOX [13] and 15-LOX [37] are expressed by intestinal epithelial cells and that there is differentiated expression of these enzymes during epithelial cell differentiation, these eicosanoids may also have an important role in the physiology of the epithelium.…”

Section: Role Of Eicosanoids In the Control Of Intestinal Epithelial mentioning

confidence: 99%

Role of eicosanoids on intestinal epithelial homeostasis

Ferrer

Moreno

2010

Biochemical Pharmacology

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The intestinal epithelium is a highly dynamic system that is continuously renewed by a process involving cell proliferation and differentiation. Moreover, it is the main interface with the external environment, and maintenance and regulation of the epithelial structure and epithelial barrier function are key determinants of digestive health and host well-being. The tight junction, a multiprotein complex composed of transmembrane proteins associated with the cytoskeletal peri-junctional ring of actin and myosin, is an essential component of this barrier that is strictly regulated in a spatio-temporal manner by a complex signaling network. Defects in the intestinal epithelial barrier function have been observed in inflammatory bowel disease, and a classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease. In recent years, several molecules have emerged as critical players contributing to inflammationassociated colorectal cancer. For example, eicosanoids derived from arachidonic acid are proposed as mediators involved in the regulation of epithelial structure/function. Interestingly, the tissue concentration of eicosanoids increases during mucosal inflammation and colorectal cancer development. This overview focuses on the physiological and physiopathological roles of eicosanoids in cell growth/cell differentiation/apoptosis and in the paracellular permeability of the intestinal epithelium. A better understanding of these processes will foster new ideas for the development of therapies for these chronic disorders.

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“…Available data suggest that lipoxygenases contribute to in vivo metabolism of endobiotics and xenobiotics in mammals (Kulkarni, 2001). Recent reviews describe the role of lipoxygenase in cancer (Bhattacharya et al, 2009;Pidgeon et al, 2007;Moreno, 2009), inflammation (Duroudier et al, 2009;Hersberger, 2010) and vascular biology (Chawengsub et al, 2009;Mochizuki & Kwon, 2008) and for an extensive presentation of the role of eicosanoids in prevention and management of diseases the reader is referred to the review of Szefel et al (2011).…”

Section: In Humansmentioning

confidence: 99%

Inhibition of Soybean Lipoxygenases – Structural and Activity Models for the Lipoxygenase Isoenzymes Family

Chedea¹,

Jisaka²

2011

Recent Trends for Enhancing the Diversity and Quality of Soybean Products

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New aspects of the role of hydroxyeicosatetraenoic acids in cell growth and cancer development

Cited by 143 publications

References 94 publications

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts

Role of eicosanoids on intestinal epithelial homeostasis

Inhibition of Soybean Lipoxygenases – Structural and Activity Models for the Lipoxygenase Isoenzymes Family

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