New aspects of the clinicopathological features and treatment of mycosis fungoides and Sézary syndrome

Furue, Masutaka; Kadono, Takafumi

doi:10.1111/1346-8138.13083

Cited by 12 publications

(12 citation statements)

References 46 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cutaneous T-cell lymphoma (CTCL) are a heterogeneous group of non-Hodgkin's lymphoma that primarily affects the skin [103]. Mycosis fungoides (MF) is the most common CTCL type, representing 50-73% of cases, with a prolonged clinical course that progresses over years through patch, plaque, and tumor stages [104]. Sézary syndrome (SS) is a leukemic variant of CTCL with a poor prognosis.…”

Section: Mycosis Fungoides and Sézary Syndromementioning

confidence: 99%

“…Additionally, IL-25 is highly expressed in CTCL and promotes the production of Th2 cytokines, in particular IL-13, and eosinophil infiltration. Moreover, TSLP activates dendritic cells to induce Th2-mediated inflammation, and periostin induces chronic inflammation by stimulating TSLP production in CTCL [104,106,107]. This polarized Th2 cytokine pattern is less prominent in the early stages of MF, when Th1-derived IFN-γ is frequently detected, and emerges more markedly with time, as the Th2-bias of malignant T cells [106,107].…”

Section: Mycosis Fungoides and Sézary Syndromementioning

confidence: 99%

See 1 more Smart Citation

Pruritus as a Distinctive Feature of Type 2 Inflammation

et al. 2021

View full text Add to dashboard Cite

Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities. We review the role of type-2 inflammation and immunity in the pathogenesis of chronic pruritic conditions of the skin. Type 2 cytokines, including IL-4, IL-13, thymic stromal lymphopoietin, periostin, IL-31, IL-25, and IL-33 are released by mast cells, innate lymphoid cells 2, keratinocytes, and type 2 T lymphocytes, and are master regulators of chronic itch. These cytokines might act as direct pruritogen on primary sensory neurons (pruriceptors) or alter the sensitivity to other itch mediators Type 2 inflammation- and immunity-dominated skin diseases, including atopic dermatitis, prurigo nodularis, bullous pemphigoid, scabies, parasitic diseases, urticaria, and Sézary syndrome are indeed conditions associated with most severe pruritus. In contrast, in other skin diseases, such as scleroderma, lupus erythematosus, hidradenitis suppurativa, and acne, type 2 inflammation is less represented, and pruritus is milder or variable. Th2 inflammation and immunity evolved to protect against parasites, and thus, the scratching response evoked by pruritus might have developed to alert about the presence and to remove parasites from the skin surface.

show abstract

Section: Mycosis Fungoides and Sézary Syndromementioning

confidence: 99%

Section: Mycosis Fungoides and Sézary Syndromementioning

confidence: 99%

Pruritus as a Distinctive Feature of Type 2 Inflammation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In Japan, bexarotene and etretinate have been used as an oral retinoid therapy for treatment of CTCL . In fMF, a good response to bexarotene was observed in a significant number of patients including partial or even complete response .…”

Section: Folliculotropic Mfmentioning

confidence: 99%

“…In Japan, bexarotene and etretinate have been used as an oral retinoid therapy for treatment of CTCL. [21][22][23][24][25] In fMF, a good response to bexarotene was observed in a significant number of patients including partial or even complete response. 12,26 Combination of psoralen plus ultraviolet (UV)-A and bexarotene has been a treatment choice for fMF.…”

Section: Folliculotropic Mfmentioning

confidence: 99%

Two distinct variants of mycosis fungoides (MF): Folliculotropic MF and erythrodermic MF

Kamijo

Sugaya

2019

The Journal of Dermatology

View full text Add to dashboard Cite

Mycosis fungoides (MF) is the most frequent type of cutaneous T‐cell lymphoma. Folliculotropic MF (fMF) and erythrodermic MF (eMF) are two distinct variants of MF. Both variants have been considered aggressive and most cases are less responsive to standard skin‐directed therapies than classical MF. We, however, experienced many cases with fMF or eMF who showed indolent clinical courses. In this article, we reviewed 10 cases with fMF and 13 cases with eMF who came to our department between 2005 and 2017. In patients with fMF, monotherapy with topical corticosteroid was effective in two cases (20%) and ultraviolet phototherapy with oral retinoid controlled disease activity in two cases (20%). Five patients with eMF (38%) responded well to ultraviolet phototherapy. In conclusion, patients with early fMF and a subgroup of eMF patients have an indolent disease course, as was proposed among the specialists. Skin‐directed therapies are preferable rather than aggressive treatment in those cases.

show abstract

“…Because of the referred worsening of cutaneous clinical manifestations, we decided to perform new biopsies of skin lesions and immunohistochemical analysis revealed an epidermotropic lymphocytic infiltrate. The histological and immunohistochemical procedures were carried out according to the previously described methods ( 4 , 7 , 8 ). The immunohistochemical analyses, performed by using the antibodies listed in Table I , revealed a pattern with simultaneous presence of CD3 + , CD4 + and CD7 − antigens, confirming the diagnosis of MF ( Fig.…”

Section: Case Reportmentioning

confidence: 99%

Mycosis fungoides and gastric T‑cell lymphoma: A case report

et al. 2020

View full text Add to dashboard Cite

Mycosis fungoides (MF) is a cutaneous malignant lymphoma with an extended clinical course. MF presents in series of dermatological manifestations, beginning with patches and plaques of the skin, and eventually evolving into tumours. Often MF can occur for extended periods without worsening of external symptoms, while the disease advances internally in organs such as lymph nodes, liver, spleen, lung, bone marrow, gastrointestinal tract, pancreas and kidney. The present report presents a clinical case in which gastrointestinal symptomatology�o��a��a��a�t��t��st��matolog� �o��a��a��a�t��t��st��matolog� ��st��matolog� ical manifestation. Immunohistochemical analysis of the skin, along with small bowel biopsies revealed evidence of gastric T��ll�lymp�oma.�To�t��b�st�o��o��knowl��g�,�t��p��s�nt� st��y�is�t��st�to��s��ib��s��a��as��in�t��lit��at��.� Case report A 65 years old woman came along to our observation at Dermatology Department in January 2012, presenting a cuta� neous eruption characterized by the occurrence of multiple an��xt�nsiv��inflammato�y��yt��mato�s�pat��s,�slig�tly� scaly. The main diameter of patches ranged, in average, from 2 cm to more than 10 cm and lesions were primarily located

show abstract

New aspects of the clinicopathological features and treatment of mycosis fungoides and Sézary syndrome

Cited by 12 publications

References 46 publications

Pruritus as a Distinctive Feature of Type 2 Inflammation

Pruritus as a Distinctive Feature of Type 2 Inflammation

Two distinct variants of mycosis fungoides (MF): Folliculotropic MF and erythrodermic MF

Mycosis fungoides and gastric T‑cell lymphoma: A case report

Contact Info

Product

Resources

About