New aspects of sepsis pathophysiology in critically ill

Abstract

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Beta-lactam antibiotics use in intensive care units - the pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach

“…Sepsis, as a systematic inflammatory response to infection, compromises a number of very complex pathophysiological processes: diffuse endothelial and epithelial injury, increased capillary permeability, impaired hemodynamics, microvascular thrombosis, tissue ischemia, apoptosis and can result in multiple organ dysfunction [1][2][3][4] . It is one of the most frequent reasons for intensive care hospitalization.…”