2008
DOI: 10.1016/s0079-6123(08)00408-1
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New aspects of oxytocin receptor function revealed by knockout mice: sociosexual behaviour and control of energy balance

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Cited by 87 publications
(77 citation statements)
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“…We examined individual differences at a polymorphic site in the oxytocin receptor (OXTR) gene, which is localized in single copy to chromosome 3 of the human genome (4). Interestingly, OXTR knockout mice display a variety of aberrant social and emotional behaviors, including increased aggression and deficits in nurturing and social memory (21,22), that are in keeping with the two hypothesized functions of oxytocin tested here. In humans, a single-nucleotide polymorphism (SNP) of an adenine (A) or guanine (G) within intron 3 of the OXTR gene (rs53576) has been associated with autism (23), a disorder characterized by impairments in social interactions and communication.…”
supporting
confidence: 79%
“…We examined individual differences at a polymorphic site in the oxytocin receptor (OXTR) gene, which is localized in single copy to chromosome 3 of the human genome (4). Interestingly, OXTR knockout mice display a variety of aberrant social and emotional behaviors, including increased aggression and deficits in nurturing and social memory (21,22), that are in keeping with the two hypothesized functions of oxytocin tested here. In humans, a single-nucleotide polymorphism (SNP) of an adenine (A) or guanine (G) within intron 3 of the OXTR gene (rs53576) has been associated with autism (23), a disorder characterized by impairments in social interactions and communication.…”
supporting
confidence: 79%
“…One of the central determinants of oxytocin functionality is the specific receptor through which oxytocin operates throughout the body and the brain (10). Indeed, animal research suggests that differences in distribution and expression of the oxytocin receptor (OXTR) underlie variation in sociability across species (11)(12)(13). Given the central role of this receptor in the functionality of oxytocin, an emergent line of inquiry has focused on the correlates of polymorphisms of the OXTR gene, located on chromosome 3p25 (14).…”
mentioning
confidence: 99%
“…In contrast to the milk ejection defect, no deficits in copulation, gestation, fecundity, or parturition have been noted in either OT Ϫ/Ϫ or Oxtr Ϫ/Ϫ mice, suggesting that these mice are typically eugonadal (5). Furthermore, compound mutants with both the Oxtr and the prostaglandin F2␣ receptor deleted exhibit no defects in parturition, indicating significant redundancy in the birth process per se (5). However, in view of the established pharmacology of circulating OT on the uterine myometrium, the possibility of a physiological action of OT during childbirth cannot be excluded, even without a loss-of-function phenotype.…”
mentioning
confidence: 92%
“…administration of recombinant OT to OT Ϫ/Ϫ mice rescues milk ejection, allowing the newborn to feed normally. In contrast to the milk ejection defect, no deficits in copulation, gestation, fecundity, or parturition have been noted in either OT Ϫ/Ϫ or Oxtr Ϫ/Ϫ mice, suggesting that these mice are typically eugonadal (5). Furthermore, compound mutants with both the Oxtr and the prostaglandin F2␣ receptor deleted exhibit no defects in parturition, indicating significant redundancy in the birth process per se (5).…”
mentioning
confidence: 95%