New Aspects of Cytochrome <i>c</i>: 3D Domain Swapping, Membrane Interaction, Peroxidase Activity, and Met80 Sulfoxide Modification

“…As another quintessential protein, cytochrome c is known as a multifunctional, water-soluble heme protein. The review article by Hirota and Nagao describes newly discovered aspects of cytochrome c, including three-dimensional domain swapping, peroxidase activity, membrane interaction, and Met80 sulfoxide modification [ 126 ]. In the mitochondrial respiratory chain, it transfers electrons from the cytochrome bc1 complex (complex III) to the cytochrome c oxidase complex (complex IV) and may also trigger apoptosis.…”

Section: Nano In Basic Biologymentioning

confidence: 99%

Molecule-to-Material-to-Bio Nanoarchitectonics with Biomedical Fullerene Nanoparticles

et al. 2022

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Nanoarchitectonics integrates nanotechnology with various other fields, with the goal of creating functional material systems from nanoscale units such as atoms, molecules, and nanomaterials. The concept bears strong similarities to the processes and functions seen in biological systems. Therefore, it is natural for materials designed through nanoarchitectonics to truly shine in bio-related applications. In this review, we present an overview of recent work exemplifying how nanoarchitectonics relates to biology and how it is being applied in biomedical research. First, we present nanoscale interactions being studied in basic biology and how they parallel nanoarchitectonics concepts. Then, we overview the state-of-the-art in biomedical applications pursuant to the nanoarchitectonics framework. On this basis, we take a deep dive into a particular building-block material frequently seen in nanoarchitectonics approaches: fullerene. We take a closer look at recent research on fullerene nanoparticles, paying special attention to biomedical applications in biosensing, gene delivery, and radical scavenging. With these subjects, we aim to illustrate the power of nanomaterials and biomimetic nanoarchitectonics when applied to bio-related applications, and we offer some considerations for future perspectives.

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“…When certain multifunctional proteins, e.g. cytochrome c, are embedded in biological membranes, the enzymatic activity and membrane interactions are strongly affected 1) . In recent years, artificial enzymes have been produced from synthetic functional proteins that realize molecular evolution 2) .…”

Section: Introductionmentioning

confidence: 99%

Inner and Interfacial Environmental Nanoarchitectonics of Supramolecular Assemblies Formed by Amphiphiles: from Emergence to Application

Akamatsu

2023

J. Oleo Sci.

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New Aspects of Cytochrome c: 3D Domain Swapping, Membrane Interaction, Peroxidase Activity, and Met80 Sulfoxide Modification

Abstract: since April 2020. His research interests include structures and functions of metalloprotein complexes at high-resolution of time and space.

Cited by 12 publications

References 128 publications

Materials nanoarchitectonics in a two-dimensional world within a nanoscale distance from the liquid phase

Materials nanoarchitectonics in a two-dimensional world within a nanoscale distance from the liquid phase

Molecule-to-Material-to-Bio Nanoarchitectonics with Biomedical Fullerene Nanoparticles

Inner and Interfacial Environmental Nanoarchitectonics of Supramolecular Assemblies Formed by Amphiphiles: from Emergence to Application

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