New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging

Павлова, О. С.; Gulyaev, Mikhail V.; Анисимов, Н.В.; Silachev, Denis N.; Gervits, L. L.; Pirogov, Y.A.

doi:10.1007/s00723-020-01242-w

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…Alike, there are two commercially available PFPE emulsions used for in vivo 19 F imaging in cell tracking studies-cell sense and V-Sense [128][129][130][131]. Perftoran ® , rebranded under the name Vidaphor TM , is a drug approved for clinical application in Russia, Mexico, Kazakhstan, Kyrgyzstan, and Ukraine, and is in the progression to be introduced in the US and European markets [132,133], to be used as a blood substitute [134]. It consists of PFD and perfluoromethyl cyclohexyl piperidine as PFCs and is stabilized by proxanol-268-polymeric surfactant and electrolyte mixture [85,133,135].…”

Section: Biomedical Applications Of Pfc Moleculesmentioning

confidence: 99%

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

et al. 2022

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Simultaneously being a non-radiative and non-invasive technique makes magnetic resonance imaging (MRI) one of the highly sought imaging techniques for the early diagnosis and treatment of diseases. Despite more than four decades of research on finding a suitable imaging agent from fluorine for clinical applications, it still lingers as a challenge to get the regulatory approval compared to its hydrogen counterpart. The pertinent hurdle is the simultaneous intrinsic hydrophobicity and lipophobicity of fluorine and its derivatives that make them insoluble in any liquids, strongly limiting their application in areas such as targeted delivery. A blossoming technique to circumvent the unfavorable physicochemical characteristics of perfluorocarbon compounds (PFCs) and guarantee a high local concentration of fluorine in the desired body part is to encapsulate them in nanosystems. In this review, we will be emphasizing different types of nanocarrier systems studied to encapsulate various PFCs and fluorinated compounds, headway to be applied as a contrast agent (CA) in fluorine-19 MRI (19F MRI). We would also scrutinize, especially from studies over the last decade, the different types of PFCs and their specific applications and limitations concerning the nanoparticle (NP) system used to encapsulate them. A critical evaluation for future opportunities would be speculated.

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Section: Biomedical Applications Of Pfc Moleculesmentioning

confidence: 99%

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

et al. 2022

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An integrated ICP-MS-based analytical approach to fractionate and characterize ionic and nanoparticulate Ce species

2022

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Multinuclear MRI Research

Pirogov

2021

Appl Magn Reson

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The presented data clearly demonstrate that multinuclear MRI has a great potential in research and clinical fields. The biomedical value of many heavy nuclei that are part of drugs, contrast agents, and molecular complexes in live tissues emphasizes the need for creating and using MRI scanners tuned to the Larmor frequencies of such nuclei. This article discusses a number of specific problems solved with the use of multinuclear MRI. Since the sensitivity of the MRI on heavy nuclei, as a rule, is insufficient for obtaining images of satisfactory quality, it is proposed to use hyperpolarization techniques for preparing objects for the MRI diagnostics. However, bearing in mind the high cost of hyperpolarization techniques, alternative approaches using contrast agents normally absent in tissues can be more suitable in certain situations. For instance, due to the absence of fluorine in the body, 19 F MRI allows for successful diagnostics of the respiratory tract and lungs filled with fluorine-containing gas, detecting the location of the blood substitute Perftoran® in the body, monitoring the transport along the gastrointestinal tract of a capsule filled with a preparation containing fluorine-19 nuclei, etc. The possibility of non-invasive local measurements of the concentration of sodium-23 in the body, which, in case of a deviation from the norm, is linked to such pathologies as diabetes, hypertension, renal failure, and many others, is also demonstrated. Reported as well is the creation of transmitting and receiving infrastructure that makes possible effective MRI measurements at low fields (of about 0.5 T) at 10 Larmor frequencies corresponding to the nuclei of hydrogen, deuterium, fluorine, boron, chlorine, sodium, carbon, phosphorus, silicon and oxygen.

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New Aspects of Biodistribution of Perfluorocarbon Emulsions in Rats: Thymus Imaging

Cited by 6 publications

References 21 publications

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

An integrated ICP-MS-based analytical approach to fractionate and characterize ionic and nanoparticulate Ce species

Multinuclear MRI Research

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