New Aspects in the Stereoselective Ethynylation of β‐C‐Glycoside Aldehydes. Application to the Synthesis of an Ambruticin Fragment.

Abstract

Carbohydrates Carbohydrates U 0500 New Aspects in the Stereoselective Ethynylation of β-C-Glycoside Aldehydes. Application to the Synthesis of an Ambruticin Fragment. -The stereoselective outcome of the ethynylation strongly depends on the nature of organometallic alkyne and the C-6 substituent of the glycoside. The method is applied to the synthesis of the C1-C13 unit (XI) of ambruticin. -(MICHELET*, V.; ADIEY, K.; TANIER, S.; DUJARDIN, G.; GENET, J.-P.; Eur.