New aspects concerning the mechanism of action of tranquilizers. The influence of some tranquilizers on protein and nucleic acid syntheses

Khafagy, Ekram Z.; Ellaithy, Amr; El-Makkawi, H.K.; El-Darawy, Z.I.

doi:10.1016/0006-2952(77)90107-1

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1979

2004

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Cited by 6 publications

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“…Albumin synthesis or secretion may have fallen during treatment. Past literature suggests that neuroleptics can inhibit protein synthesis in bacteria (16), and amino acid synthesis in humans (17). Dickes, Schenker and Deutsch (18) found decreased globulin in humans following chronic neuroleptic medication.…”

Section: Discussionmentioning

confidence: 99%

Clinical Blood Chemistry Values and Long Acting Phenothiazines

Schneider

Kirby

1981

Pharmacopsychiatry

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Fifty-nine chronic schizophrenic patients received one year of treatment with either fluphenazine enanthate or pipothiazine palmitate IM. Both long acting neuroleptics significantly decreased serum albumin, total protein and creatinine values. Triglycerides were decreased only early in treatment. Pretreatment findings from therapy responders, as compared with those who failed to respond to treatment, included higher albumin values and to a lesser extent, lower lactic dehydrogenase values and greater height. These results were discussed with an eye toward the hepatocellular effects of long acting phenothiazines and the effect of liver function on the pharmacokinetics of these medications.

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Section: Discussionmentioning

confidence: 99%