New artificial network model to estimate biological activity of peat humic acids

Zykova, M. V.; Brazovsky, K. S.; Veretennikova, Elena E.; Данилец, М. Г.; Logvinova, L. A.; Романенко, С. В.; Trofimova, E. S.; Ligacheva, A. A.; Bratishko, Kristina A.; Yusubov, Mekhman S.; Lyapkov, A. A.; Белоусов, Михаил Валерьевич

doi:10.1016/j.envres.2020.109999

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…The IR spectra of the prepared humates showed the presence of OH groups polymer linked by intermolecular hydrogen bonds (3400 cm −1 ), the presence of СН, СН 2 , and СН 3 groups (stretching vibrations in aliphatic chains at 2870 cm −1 ), the presence of carboxyl groups (1720 cm −1 ) and quinones (1640–1680 cm −1 ), the stretching mode of conjugated double bonds (1650–1620 cm −1 ), the bending mode of СН groups (1420 cm −1 ), and the asymmetric stretching mode inСОС groups (1250 cm −1 ) and the symmetric stretching mode in these groups (1030 cm −1 ). The data obtained indicate the proximity of the selected substances to humates, which is proved by the data presented in the literature 31–40 …”

Section: Resultssupporting

confidence: 60%

“…FA differs from HA in the presence of highly reactive COH groups. Note that, in addition to the peak at 1329 cm −1 , the spectrum contains a well‐read peak at 615 cm −1 , corresponding to the in‐plane stretching mode of the OH group; the aforementioned groups were found by a number of researchers 33,39,40 who characterized these peaks as a part of the HA IR‐spectra structure. As can be seen from Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The data obtained indicate the proximity of the selected substances to humates, which is proved by the data presented in the literature. [31][32][33][34][35][36][37][38][39][40] First, the solid phase (filter residue) of the chicken manure obtained after subcritical water extraction is not proposed for future application as a fertilizer. Furthermore, this solid phase was devoid of the most valuable extractable raw material HA, as well as FA.…”

Section: Resultsmentioning

confidence: 99%

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Subcritical water extraction of organic acids from chicken manure

et al. 2020

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BACKGROUND Chicken manure waste has a wide range of organic substances and mineral elements. This enriched source has stimulated great scientific interest in finding cleaner and more environmentally benign nutrient recovery options. This study aimed to determine an effective and eco‐friendly method (i.e. subcritical water extraction) for processing fresh poultry manure. RESULTS The high content of total organic carbon, including humic acids carbon and fulvic acids carbon, in extract was found to release under subcritical conditions. The organic compounds obtained by extraction with subcritical water correspond to humic acid in composition because of the presence in the sample of all the functional groups: polymer bonded by molecular hydrogen bond (3400 cm−1), the presence of CH2 and CH3 groups (2870 cm−1), the presence of carboxyl groups (1720 cm−1) and quinones (1640–1680 cm−1). The solid phase left over was characterized by a high content of organic carbon, phosphorus, potassium, and microelements. The maximum extraction of humic acid and fulvic acid carbon was found between 210 and 250 °C at a pressure of 50–60 atm, and the content was a maximum of 3647.2 × 10−6 g kg−1 at an extraction temperature of 250 °C. CONCLUSION Given the high content of humic acid found in the extracted medium, the proposed subcritical extraction opens up new opportunities for nutrients recovery in the poultry industry. © 2020 Society of Chemical Industry

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Section: Resultssupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Subcritical water extraction of organic acids from chicken manure

et al. 2020

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“…They are characterized by a broad range of molecular weights and also exhibit colloidal properties. While HSs from different sources share some molecular parameters, each HS is overall unique in its composition [8][9][10][11][12][13][14]. Therefore, HSs are exceedingly complex natural entities for research and necessitate specific methodological approaches.…”

Section: Introductionmentioning

confidence: 99%

Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties

Zykova,

Bratishko,

Buyko

et al. 2024

Molecules

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An investigation was carried out on humic substances (HSs) isolated from the coal of the Kansk-Achinsk basin (Krasnoyarsk Territory, Russia). The coal HSs demonstrate the main parameters of molecular structure inherent to this class of natural compounds. An assessment was performed for the chemical, microbiological, and pharmacological safety parameters, as well as the biological efficacy. The HS sample meets the safety requirements in microbiological purity, toxic metals content (lead, cadmium, mercury, arsenic), and radionuclides. The presence of 11 essential elements was determined. The absence of general, systemic toxicity, cytotoxicity, and allergenic properties was demonstrated. The coal HS sample was classified as a Class V hazard (low danger substances). High antioxidant and antiradical activities and immunotropic and cytoprotective properties were identified. The ability of the HS to inhibit hydroxyl radicals and superoxide anion radicals was revealed. Pronounced actoprotective and nootropic activities were also demonstrated in vivo. Intragastric administration of the HS sample resulted in the improvement of physical parameters in mice as assessed by the “swim exhaustion” test. Furthermore, intragastric administration in mice with cholinergic dysfunction led to a higher ability of animals with scopolamine-induced amnesia to form conditioned reflexes. These findings suggest that the studied HS sample is a safe and effective natural substance, making it suitable for use as a dietary bioactive supplement.

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“…Additionally, the application of tandem mass spectrometry within the dereplication strategy is almost impossible due to its time-consuming nature, even with the most powerful Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) techniques [20]. Instead, the integral structural parameters are investigated in order to build up a chemical foundation for biological properties [21,22]. In addition, the correlation of the abundance of molecular components with the biological response in a set of similar samples or during bulk fractionation can be used to prioritize components in a mixture [23,24].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Lignin-Derived Polyphenols Dereplicated Using High-Resolution Mass Spectrometry, In Vivo Experiments, and Deep Learning

Orlov

Semenov

Rukhovich

et al. 2022

IJMS

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Chronic liver diseases affect more than 1 billion people worldwide and represent one of the main public health issues. Nonalcoholic fatty liver disease (NAFLD) accounts for the majority of mortal cases, while there is no currently approved therapeutics for its treatment. One of the prospective approaches to NAFLD therapy is to use a mixture of natural compounds. They showed effectiveness in alleviating NAFLD-related conditions including steatosis, fibrosis, etc. However, understanding the mechanism of action of such mixtures is important for their rational application. In this work, we propose a new dereplication workflow for deciphering the mechanism of action of the lignin-derived natural compound mixture. The workflow combines the analysis of molecular components with high-resolution mass spectrometry, selective chemical tagging and deuterium labeling, liver tissue penetration examination, assessment of biological activity in vitro, and computational chemistry tools used to generate putative structural candidates. Molecular docking was used to propose the potential mechanism of action of these structures, which was assessed by a proteomic experiment.

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New artificial network model to estimate biological activity of peat humic acids

Cited by 11 publications

References 26 publications

Subcritical water extraction of organic acids from chicken manure

Subcritical water extraction of organic acids from chicken manure

Coal-Derived Humic Substances: Insight into Chemical Structure Parameters and Biomedical Properties

Hepatoprotective Activity of Lignin-Derived Polyphenols Dereplicated Using High-Resolution Mass Spectrometry, In Vivo Experiments, and Deep Learning

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