1985
DOI: 10.1017/s0016672300022254
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New ara-C resistant mutants of the Chinese hamster ovary cells

Abstract: Mutants of Chinese hamster ovary (CHO) cell resistant to cytosine arabinoside (ara-C), an inhibitor of DNA synthesis and antitumour drug, have been isolated and characterized both biochemically and genetically. Mutants occurring spontaneously and those induced by treatment with 2V r -methyl-2V y -Nitro-.A r -nitrosoguanidine (MNG), were obtained at a frequency of 0-24 x 10~6 and 3-4 x 10~6 respectively. The mutants showed a stable ara-C resistant phenotype which was inherited as a dominant trait in genetic cro… Show more

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