Abstract:Aim:The purpose was to study the effect of actovegin on the formation of reactive oxygen species by blood phagocytes of patients with heart failure and on SK-N-SH neuron necrosis. Materials and methods: The generation of superoxide anion (O 2 -•) were recorded on whole blood samples (50-100 µl). Change lucigenin-dependent hemiluminescence determined on a hemi-luminometer «Biotoks-7». As a stimulator of the phagocyte phorbol ester (PMA, 1 µm) was used. Necrosis of neurons induced by hydrogen peroxide was deter… Show more
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