New approach to ‘top‐and‐bottom’ whole blood separation using the multiunit <scp>TACSI WB</scp> system: quality of blood components

Lotens, Anaïs; Najdovski, Tomé; Cellier, Nicolas; Ernotte, B.; Lambermont, Micheline; Rapaille, A.

doi:10.1111/vox.12159

Cited by 11 publications

(8 citation statements)

References 24 publications

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“…T A B L E 1 Summary of included studies in this review. Retrospective study in a blood bank centre of the quality of the RCC and platelet concentrates prepared with the semi-automated (TAT) processing method [16] Gkoumassi E 2012 Prospective study in a blood bank centre on the cell injury and haemolysis from RBCs during processing and storage using a semi-automated (BAT) processing method [17] Hansen AL 2015 Prospective study in a blood bank centre on the in vitro characteristics of RCCs produced by different methods (apheresis, LR and non-LR with buffy coat method) [18] Johnson L 2013 Prospective assessment in a blood bank centre of the blood components processed with the automated (Reveos) system and compared with data from the semi-automated method [19] Jordan A 2016 Retrospective, multi-centre study on the quality control data from RCCs to assess the sources of variability (pre-storage, donor characteristics, buffy coat vs. TAT processing method) [20] Jurado M 2012 Prospective assessment in a blood bank centre of the blood components processed with an automated (Atreus 3C) system and compared with data from the Buffy coat method [21] Lagerberg JW 2013 Prospective assessment in a blood bank centre of the blood components and operational efficiencies obtained using the automated (Reveos) processing system [22] Lotens A 2014 Prospective comparison in a blood bank centre of the blood components processed using an apheresis (TACSI) method versus using a semi-automated (buffy coat) method [23] Malvaux N 2021 Prospective comparison in a blood bank centre of the blood components processed with a semi-automated (buffy coat) system versus. using the automated (Reveos) system [24] Mastronardi C 2013 Prospective study in a blood bank centre on the impact that manual mixing of whole blood has on the product quality before the first centrifugation using the buffy coat method [25] McAteer MJ 2010 Prospective, multi-center analysis on RCCs' haemolysis and assessment on the link with donor characteristics and processing method used (manual, semi-automated and automated)…”

Section: F I G U R E 3 Flow Diagram Of Study Inclusion Using Medline ...mentioning

confidence: 99%

Comparison of automated versus semi‐automated whole blood processing systems: A systematic review

et al. 2023

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Background and Objectives Implementation of automated steps in preparing blood components for transfusion from whole blood collections has produced improvements in multiple fields. The aim of this review is to summarize data from existing literature related to automation of whole blood processing systems. Materials and Methods We searched MEDLINE for studies comparing semi‐automated and fully automated whole blood processing systems published before 20 July 2021. Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines were followed. Additionally, we performed a manual search. Results We identified 500 studies, of which 459 (92%) did not meet the eligibility criteria, and finally 17 studies were included in the analysis. Manual search included six additional studies. Publication year ranged from 2004 to 2021. Automation reduced the run‐time (from 92 to 76 min), improved recovery of haemoglobin in red cell concentrates (RCCs) and resulted in higher red blood cell and platelet yields. Automation also reduced discard rates due to whole blood bag ruptures (1.2%–0.1%), low volume of RCCs (<200 ml; 0.5%–0.03%) and haemolytic plasma (2.1%–0.6%). Automation could reduce the number of full‐time equivalent (FTE) operators or maintain the number of FTE operators while performing additional procedures, and it reduced to 1.13 m2 the space required for the device. Conclusion Automation of whole blood processing resulted in continued improvements in productivity, product quality and technical features. However, too few publications are available to reach strong conclusions. Therefore, it is necessary to expand the scientific knowledge in this field.

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Section: F I G U R E 3 Flow Diagram Of Study Inclusion Using Medline ...mentioning

confidence: 99%

Comparison of automated versus semi‐automated whole blood processing systems: A systematic review

et al. 2023

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“…Furthermore, as the size of the device increases, physical shear forces on the cells during TASCI® PL (Terumo Automated Centrifuge and Separator Integration System for Platelets) is a closed, integrated manufacturing system that can process up to six buffy-coats at a time into platelet concentrate by first pooling and centrifugation of the buffy coats followed by pump-operated filtration for separation and leukoreduction of the final platelet product. Reports show that the system, which is used most commonly in blood centers, achieves efficient platelet recovery [26] suitable for clinical use [27].…”

Section: Centrifugal Counterflow Elutriationmentioning

confidence: 99%

Challenges and advances in scale-up of label-free downstream processing for allogeneic cell therapies

Masri¹,

Hoeve

Sousa

et al. 2017

Cell Gene Therapy Insights

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“…Use of totally automated component separator instrument will allow for the preparation of low volume BCs with a recovery of 90% of whole blood platelets. [ 4 ]…”

Section: General Principles Of Component Preparationmentioning

confidence: 99%

Overview of blood components and their preparation

2014

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The whole blood which is a mixture of cells, colloids and crystalloids can be separated into different blood components namely packed red blood cell (PRBC) concentrate, platelet concentrate, fresh frozen plasma and cryoprecipitate. Each blood component is used for a different indication; thus the component separation has maximized the utility of one whole blood unit. Different components need different storage conditions and temperature requirements for therapeutic efficacy. A variety of equipments to maintain suitable ambient conditions during storage and transportation are in vogue. The blood components being foreign to a patient may produce adverse effects that may range from mild allergic manifestations to fatal reactions. Such reactions are usually caused by plasma proteins, leucocytes, red cell antigens, plasma and other pathogens. To avoid and reduce such complications, blood products are modified as leukoreduced products, irradiated products, volume reduced products, saline washed products and pathogen inactivated products. The maintenance of blood inventory forms a major concern of blood banking particularly of rare blood groups routinely and common blood groups during disasters. PRBCs can be stored for years using cryopreservation techniques. New researches in red cell cultures and blood substitutes herald new era in blood banking.

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New approach to ‘top‐and‐bottom’ whole blood separation using the multiunit TACSI WB system: quality of blood components

Abstract: From these in vitro data, red blood cell concentrates produced using TACSI whole blood are suitable for clinical use with a quality at least equivalent to the control group.

Cited by 11 publications

References 24 publications

Comparison of automated versus semi‐automated whole blood processing systems: A systematic review

Comparison of automated versus semi‐automated whole blood processing systems: A systematic review

Challenges and advances in scale-up of label-free downstream processing for allogeneic cell therapies

Overview of blood components and their preparation

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