New approach to dextran derivatives containing primary amino functions

Vandoorne, Filip; Bruneel, Dorine; Vercauteren, R.; Schacht, Etienne

doi:10.1002/macp.1991.021920318

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…First, dextran was activated. Several activation methods for polymer contained hydroxyl have been considered: tosylation,18 esterification using 4‐nitrophenyl chloroformate,19, 20 carbonyl diimidazole,21 cyanogen halide,22 and so on. In our work, 4‐nitrophenyl chloroformate was selected for the activation of hydroxyl groups of dextran and synthesis dextran‐pNP in copolymer [Scheme (a)].…”

Section: Resultsmentioning

confidence: 99%

Novel amphiphilic dextran copolymers nanoparticles for delivery of doxorubicin

Gao

2010

J of Applied Polymer Sci

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In this work, a novel biodegradable amphiphilic copolymer based on dextran and 1,2-dipalmitoylsn-glycero-3-phosphoethanolamine (DPPE) was successfully prepared. The amphiphilic copolymer may self-assemble into polymeric micelles in an aqueous solution. Fluorescence spectroscopy, dynamic light scattering (DLS), and a transmission electron microscope (TEM) method confirmed the formation of copolymeric micelles. To estimate the feasibility as novel drug carriers, doxorubicin (DOX) was incorporated into polymeric nanoparticles. The DOX-loaded nanoparticles exhibited greater antitumor effect than free DOX for HeLa celles, suggesting that the dextran/DPPE nanoparticles have great potential as a tumor targeting drug carrier.

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Section: Resultsmentioning

confidence: 99%

Novel amphiphilic dextran copolymers nanoparticles for delivery of doxorubicin

Gao

2010

J of Applied Polymer Sci

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“…Several activation methods for polymer contained hydroxyl have been considered: tosylation,23, 24 esterification using 4‐nitrophenyl chloroformate,25–27 carbonyl diimidazole,28 cyanogen halide,29 and so on. In our work, 4‐nitrophenyl chloroformate was selected for the activation of hydroxyl groups of Pluronic (F68) in copolymer [Scheme (a)].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of amphiphilic pluronic (F68)‐1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphoethanolamine copolymers and their micelles as a drug carrier

Wang

Zeng

2010

J of Applied Polymer Sci

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A new Pluronic (F68)-1,2-dipalmitoyl-snglycero-3-phosphoethanolamine (DPPE) (Pluronic (F68)-DPPE) copolymer was synthesized with Pluronic (F68) and DPPE. The chemical structure and physical properties of copolymers were determined by FTIR, 1 H NMR, 13 C NMR, 31 P NMR, and TGA. Environmental scanning electron microscopy, fluorescence spectroscopy, and dynamic light scattering method confirmed the formation of copolymeric micelles of Pluronic (F68)-DPPE. To estimate the feasibility as novel drug carriers, the copolymer micelles were prepared by the phase separation dialysis method. Amphotericin B as a lipophilic model drug was incorporated into copolymeric micelles and the drug release behavior was investigated. It was found that the chemical composition of the micelle was a key factor in controlling micelles size, drug-loading content, and drug release behavior. As DPPE segment weight ratio increased, the micelle size and drug-loading content increased, and the drug release rate decreased.

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“…The pure substance exists as colourless orthorhombic crystals or yellow monoclinic needles with a molecular weight of 227. 13. Ingestion of TNT may cause liver damage, gastritis, aplastic anemia, cyanosis and dermatitis.…”

Section: Introductionmentioning

confidence: 99%

Electrochemiluminescence enzyme immunoassay for TNT

Wilson

Clavering

Hutchinson

2003

Analyst

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Details of an electrochemiluminescence (ECL) enzyme immunoassay for TNT (2,4,6-trinitrotoluene) are reported. The design and construction of a computer controlled flow injection electrochemiluminometer in which the immunoassays are carried out is described. This system is used to select and pump solutions through a flow cell, which contains a gold working electrode as part of a three-electrode arrangement. The deposition of a re-usable immunosorbent dextran surface anchored to a gold surface in the flow cell by chemiadsorbed thiol groups is described. Antibodies are labeled with the enzyme glucose oxidase and used in competitive immunoassays in which the separation step is carried out by concentrating unbound antibodies on the immunosorbent surface. Hydrogen peroxide generated by the enzyme label when glucose is pumped through the flow cell is detected using luminol ECL. Light intensity was inversely proportional to the concentration of TNT in the sample in the range 0-100 ppb. The results are compared with colorimetric ELISA's carried out using the same reagents, and potential for developing a portable instrument for use in the field is discussed.

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New approach to dextran derivatives containing primary amino functions

Cited by 13 publications

References 9 publications

Novel amphiphilic dextran copolymers nanoparticles for delivery of doxorubicin

Novel amphiphilic dextran copolymers nanoparticles for delivery of doxorubicin

Synthesis and characterization of amphiphilic pluronic (F68)‐1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphoethanolamine copolymers and their micelles as a drug carrier

Electrochemiluminescence enzyme immunoassay for TNT

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