New approach for the measurement of long-term alcohol consumption trends: Application of wastewater-based epidemiology in an Australian regional city

Zheng, Qiuda; Tscharke, Benjamin J.; Krapp, Catharina; O’Brien, Jake; Mackie, Rachel; Connor, Jason P.; Mueller, Jochen F.; Thomas, Kevin V.; Thai, Phong K.

doi:10.1016/j.drugalcdep.2019.107795

Cited by 36 publications

(36 citation statements)

References 31 publications

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“…The average consumption measured on Sunday was about twice the consumption measured on other days of the week including Saturday (U = 198, P = 0.002). This pattern is slightly different from the weekly pattern of alcohol detection seen in other Western countries, where a significant increase in alcohol detection is typically observed on both Saturday and Sunday, for example, in Norway [27], Belgium [28] or Australia [29].…”

Section: Alcohol Consumptioncontrasting

confidence: 84%

“…The alcohol consumption pattern during the New Year holiday observed in this study reflects Russian New Year holidays, characterised by a week of national holidays starting on New Year's Eve and ending with the Orthodox Russian Christmas day on 7 January 2019. The pattern of higher consumption during Christmas and New Year is also observed in Australia, where WBE data on the Christmas and New Year period are available [15,29,30].…”

Section: Alcohol Consumptionmentioning

confidence: 57%

“…It could be hypothesised that lower consumption on that day may be related to delayed commencement of smoking on 2 January due to a peak in celebratory events. Other previous studies also reported that variations between daily tobacco use estimates between daily tobacco use estimates can be up to threefold [29,37].…”

Section: Tobacco Consumptionmentioning

confidence: 76%

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Estimating population‐level of alcohol, tobacco and morphine use in a small Russian region using wastewater‐based epidemiology

Rozhanets

Thai

Silantyev

et al. 2021

Drug and Alcohol Review

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Introduction. Alcohol, tobacco and illicit drug use combined are the largest modifiable health risk factors. Wastewater-based epidemiology (WBE) is a complementary approach for monitoring substance use in the population. In this study we applied WBE technique to a community in the Moscow region to estimate population-level consumption of alcohol, tobacco and morphine. Methods. Wastewater sampling was carried out over 47 days, in 2018 and 2019, including the New Year period. Analysis of the samples for consumption biomarkers (ethyl sulphate, cotinine and morphine) were undertaken using liquid chromatography tandem mass spectrometry (LC-MS/MS). Daily consumption estimates were then compared with sales/production/prescription data and between different days of the week using Mann-Whitney U test. Results. Alcohol consumption was significantly higher on Sundays and during the New Year and Russian Christmas period compared to weekdays and Saturdays. Tobacco consumption estimates were largely consistent throughout the week. Morphine was detected by WBE during the monitoring period but was inconsistent with prescription record data. Discussion and Conclusions. This study provides evidence for the feasibility of conducting WBE in Russia. Estimates of alcohol consumption derived from WBE were higher than average alcohol sales data for the country. The estimated consumption of nicotine is generally consistent with the production data, with estimates higher than in most other countries. Our results also suggest potential illegal use of opioids (morphine-based) in the population. Given the considerable health and economic costs of substance use in Russia, more extensive WBE testing is recommended to inform and evaluate public health policies.

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Section: Alcohol Consumptioncontrasting

confidence: 84%

Section: Alcohol Consumptionmentioning

confidence: 57%

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Estimating population‐level of alcohol, tobacco and morphine use in a small Russian region using wastewater‐based epidemiology

Rozhanets

Thai

Silantyev

et al. 2021

Drug and Alcohol Review

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“…A CF of 4 × 10 3 is higher than the CF of 3042 that has been used in most of the WBE studies to date (see Table ). The latter was estimated based only on the excretion factor of 0.012% for EtS proposed by Rodriguez-Alvarez et al It is still lower than the CF value of 3590 used by Zheng et al where Deg EtS was included.…”

Section: Resultsmentioning

confidence: 94%

“…The degradation of EtS (Deg EtS ) has been reported in several WBE studies since it was first proposed as a WBE biomarker including significant degradation under real sewer conditions, , but so far, to our knowledge, only one study attempted to incorporate this parameter into the WBE back estimation of alcohol consumption . At the same time, the current excretion rate for EtS (ER EtS ) is derived from only three pharmacokinetic studies with limited numbers (from 6 to 18) of participants , that may not be representative of the general population, and it was suggested that there is clear scope for revision when new data become available. ,, …”

Section: Introductionmentioning

confidence: 99%

Estimating Alcohol Consumption by Wastewater-Based Epidemiology: An Assessment of the Correction Factor for Ethyl Sulfate Using Large-Scale National Monitoring Data

Thai

Tscharke

O’Brien

et al. 2021

Environ. Sci. Technol. Lett.

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The correction factor (CF) of the alcohol biomarker ethyl sulfate (EtS), an important parameter for back-estimating alcohol consumption via wastewater-based epidemiology (WBE), reportedly has a large uncertainty due to the limited size of relevant pharmacokinetic studies. We applied an alternative approach to derive an EtS CF by comparing the sales data with the total load measured by WBE across Australia. We utilized EtS data from the National Wastewater Drug Monitoring Program in Australia from 2016 to 2019, that covered more than 50% of the Australian population. National sales data for alcohol were obtained from the Australian Bureau of Statistics from 2016 to 2018the most recent data available. A new CF of 4 × 103 was suggested for EtS, significantly greater than the CFs that have been used previously (3042 or 3320). This new CF was applied to a separate multiple-year set of WBE data for EtS from an Australian town and generated estimates that better match sales data than the previous CFs. The new CF incorporates both the excretion rate and sewer degradation of EtS and hence is likely to improve the future accuracy of alcohol consumption estimates by WBE.

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Wastewater‐based Epidemiology to Investigate Spatio‐Temporal Trends in Alcohol Consumption in Aotearoa, New Zealand

Wilson,

Phung,

Chappell

et al. 2024

Chemistry An Asian Journal

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Alcohol is an influential drug that has extensive societal impact. In Aotearoa New Zealand, there are a number of worrying trends related to alcohol consumption including rates of alcohol‐related harm and violence and heavy episodic drinking. To understand and address these issues, alcohol consumption rates and related trends need to be understood. A wastewater‐based epidemiology study was carried out over the course of six months (April ‐ September 2021), sampling one week per month from ten catchment areas covering ~40% of the national population. The average alcohol consumption was found to be 12.2 mL/person/day. Temporal and geographical trends in alcohol consumption were found; there was higher alcohol consumption on the weekends compared to weekdays, alcohol consumption was inversely related to settlement size, there was increased alcohol consumption due to public holidays and alcohol consumption was not seen to increase during COVID restrictions, however there was a notable change in the weekly trend during lockdowns. This application of alcohol WBE to Aotearoa New Zealand represents a comprehensive national study to understand alcohol consumption and its influences. The knowledge obtained will allow appropriate services and public policies to be reviewed to best serve communities.

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New approach for the measurement of long-term alcohol consumption trends: Application of wastewater-based epidemiology in an Australian regional city

Cited by 36 publications

References 31 publications

Estimating population‐level of alcohol, tobacco and morphine use in a small Russian region using wastewater‐based epidemiology

Estimating population‐level of alcohol, tobacco and morphine use in a small Russian region using wastewater‐based epidemiology

Estimating Alcohol Consumption by Wastewater-Based Epidemiology: An Assessment of the Correction Factor for Ethyl Sulfate Using Large-Scale National Monitoring Data

Wastewater‐based Epidemiology to Investigate Spatio‐Temporal Trends in Alcohol Consumption in Aotearoa, New Zealand

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