New Approach for Sulfadiazine Toxicity Management using Carboxymethyl Cellulose Grafted Acrylamide Hydrogel

Abstract

Sulfadiazine (SZ), a small molecule sulfonamide that also named a 2-sulfanilamido-pyrimidine. SZ is an artificial bacteriostatic antibiotic through a widespread spectrum counter to numerous gram-negative and gram-positive bacteria. Sulfonamide antibiotics frequently identified in the earthly and water environment, but little acknowledgment about abiotic deprivation of these antibiotics. The SZ adsorption from aqueous solution studied in the present experiment utilizing carboxymethyl cellulose (CMC) grafted acrylamide (AM) hydrogel as an adsorbent. Effect of time-related to equilibrium, salts, temperature, and pH value was accomplished using kinetics and thermodynamic studies. Fourier-transform infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM) analysis accomplished for CMC-g-AM hydrogel before and after SZ adsorption. The study showed higher adsorption of the SZ on these hydrogels, and the degrees of SZ adsorption on the hydrogels decreased with increasing temperature (exothermic process). Adsorbed quantity of SZ on the surface was declined as the pH augmented. KCl’s influence on adsorption is more than that of NaCl, and the CaCO3 is more than of KCl. Spontaneous and feasible adsorption takes place, and adsorption of SZ on hydrogel fits well with the Freundlich model.

Prevalence of Home Storage of Medicines and Associated Factors in Iraq

“…This allows people to store medications and self-medicine at home. Drugs without a prescription, especially antimicrobial agents, have become a practice often encouraged in the Iraqi community [1], [2]. Easy access to medicines has provided a high rate of use of medicines for self-restraint diseases.…”