New applications of pyridinium ylides toward heterocyclic synthesis

Three-Component Condensation of Pyridinium Ylides, β-Ketonitriles, and Aldehydes with Divergent Regioselectivity: Synthesis of 4,5-Dihydrofuran-3- and 2H-Pyran-5-carbonitriles

“…The unique reactivities of ylides are defined by their distinctive structural elements, which involve a good heteroatom-containing leaving group and nucleophilic carbanionic site. The nature of the onium group as well as the degree of stabilization of negative charge by the neighboring groups has a decisive influence on the reactivity and scope of applications for the onium ylides …”

20 Years of Forging N-Heterocycles from Acrylamides through Domino/Cascade Reactions

“…Organic chemists have also initiated a proactive dynamic in this strategic direction which has resulted in the improvement of several chemistry research fields such as organometallic catalysis, biocatalysis, organocatalysis, promoting as well the emergence of innovative synthetic tools such as C-H functionalization, tandem and cascade /domino reactions. Domino reactions, which imply the formation of two or more bonds in one-step under the same reaction conditions as welldefined by Tietze in 1993, 1 are powerful tools allowing the construction of complex skeletons [2][3][4][5] from ideally simple starting materials [6][7][8] with greatly improved sustainability and reduced costs compared to the traditional linear synthetic approach.…”

“…Domino reactions, which imply the formation of two or more bonds in one step under the same reaction conditions, as well-defined by Tietze in 1993, 1 are powerful tools. They allow the construction of complex skeletons [2][3][4][5] from ideally simple starting materials, [6][7][8] with greatly improved sustainability and reduced costs compared to traditional linear synthetic approaches.…”

A Convenient Synthesis of Polysubstituted Coumarin‐pyrrolo[2,1‐a]isoquinoline‐1‐carbaldehydes from Isoquinoline, 2‐Bromoacetophenones and Coumarin‐β‐chlorovinyl Aldehydes

“…[1] Reactions of these ylides with various activated alkynes or olefins are currently the most preferred method for synthesizing structurally numerous heterocycles such as pyrrole derivatives, spirofused indolizines, azoles, and six-and seven-membered Nheterocycles that have many applications in medicinal chemistry and drug discovery. [2] One of the most important of these N-heterocyclic compounds is pyrroloisoquinolines targeted by organic synthesis chemists in laboratories since 1997. These compounds are found in the structure of many natural products such as Crispin, Trolling, Harmicine, Ningalins, and Lamellarin derivatives.…”