1983
DOI: 10.1126/science.6337397
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New Applications of Microbial Products

Abstract: Microbial secondary metabolites are now being used for applications other than as antibacterial, antifungal, and antitumor agents. These applications include use against parasites (coccidia, helminths) and insects as well as for animal and plant growth stimulation, immunosuppression, uterocontraction, and other pharmacological activities. Further applications are possible in various areas of pharmacology and agriculture, a development catalyzed by the use of simple enzyme assays for screening prior to testing … Show more

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Cited by 53 publications
(12 citation statements)
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“…Secondary metabolites of streptomycetes have also been reported as potential bioherbicidal agents against mono-and dicotyledenous plants (Demain, 1983). Most work has centered on using fungal antagonists or microbial toxins against diseases and weeds that have a visibly dramatic effect on crop plants and yields.…”
Section: Discussionmentioning
confidence: 99%
“…Secondary metabolites of streptomycetes have also been reported as potential bioherbicidal agents against mono-and dicotyledenous plants (Demain, 1983). Most work has centered on using fungal antagonists or microbial toxins against diseases and weeds that have a visibly dramatic effect on crop plants and yields.…”
Section: Discussionmentioning
confidence: 99%
“…This product can be produced by cultures of Penicillium species [4], A. terreus [5–7], Monascus species [8, 9], Hypomyces , Doratomyces , Phoma , Eupenicillium , Gymnoascus , and Trichoderma [10]. Although the ability of different groups of fungi for production of lovastatin was reported in many studies, only production of this compound by A. terreus was commercialized (for manufacture of high quantity of lovastatin for used as anticholesterol drag) [11]. Microorganisms are able to produce lovastatin in SSF or submerged culture [5, 7, 1215].…”
Section: Introductionmentioning
confidence: 99%
“…The list of new phytotoxins from soil fungi continues to grow. The potential to discover new antibiotics is still unlimited, and ''with regard to the application of microbial secondary metabolites for the benefit or mankind, the surface has only been scratched'' (Demain, 1983). The vast majority of the antibiotics that have so far been discovered originate from actinomycetes.…”
Section: Introductionmentioning
confidence: 99%