New application of three‐dimensional printing biomaterial in nasal reconstruction

Park, Sun Hwa; Yun, Byeong Gon; Won, Joo Yun; Yun, Won Seok; Shim, Jin Hyung; Lim, Mi Hyun; Kim, Do Hyun; Baek, Sang A.; AlAhmari, Yahya; Jeun, Jun Ho; Hwang, Se Hwan; Kim, Sung Won

doi:10.1002/lary.26400

Cited by 55 publications

(47 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PCL mesh used in the present study is thought to be adequate for enhancing cell growth and maintaining durability for sufficient mechanical resistance, this has been proven in previous animal study reporting that prominent soft tissue ingrowth and neovascularization without postoperative infection or inflammation were observed in implanted PCL mesh with this same materials and manufacturing conditions …”

Section: Resultsmentioning

confidence: 67%

“…In this study, we used a 3D printing‐based PCL structure for a auricular cartilage because the characteristics of PCL, such as the excellent mechanical properties and slow biodegradability, would help maintain the desired ear shape semipermanently . PCL is biocompatible and safely biodegradable in vivo (2–4 years) .…”

Section: Discussionmentioning

confidence: 99%

“…PCL is biocompatible and safely biodegradable in vivo (2–4 years) . It degraded by hydrolysis in slow manner that the engineered cartilage may have sufficient time to mature and gain mechanical properties . PCL can be melted at 60°C and used in a 3D printer, without the need for toxic solvents for dissolution, and extruded in a computer‐controlled pattern to construct structures layer by layer .…”

Section: Discussionmentioning

confidence: 99%

“…It degraded by hydrolysis in slow manner that the engineered cartilage may have sufficient time to mature and gain mechanical properties . PCL can be melted at 60°C and used in a 3D printer, without the need for toxic solvents for dissolution, and extruded in a computer‐controlled pattern to construct structures layer by layer . Moreover, the low melting point of PCL (60°C) allowed a small portion of PGA fibers to fuse themselves into the PCL grids during hot compression molding, making the PCL porous for cell infiltration after PGA degradation, which further facilitates the replacement of the inner core with the patient's own tissue during PCL degradation .…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Ideal scaffold design for total ear reconstruction using a three‐dimensional printing technique

Jung

Kim

et al. 2018

J Biomed Mater Res

View full text Add to dashboard Cite

Ear reconstruction using three-dimensional (3D) printing technique has been considered as a good substitute for conventional surgery, because it can provide custom-made 3D framework. However, there are difficulties with its application in clinical use. Researchers have reported 3D scaffolds for ear cartilage regeneration, but the designs of the 3D scaffolds were not appropriate to be used in surgery. Hence, we propose the design of an ideal 3D ear scaffold for use in ear reconstruction surgery. Facial computed tomography (CT) images of the unaffected ear were extracted using a "segmentation" procedure. The selected data were converted to a 3D model and mirrored to create a model of the affected side. The design of 3D model was modified to apply to Nagata's two-stage surgery. Based on the 3D reconstructed model, a 3D scaffold was 3D printed using polycaprolactone. The 3D scaffold closely resembled the real cartilage framework used in current operations in terms of ear anatomy.To account for skin thickness, the 3D scaffold was made 4 mm smaller than the real ear. Furthermore, 2 mm pores were included to allow the implantation of diced cartilage to promote regeneration of the cartilage. 3D printing technology can overcome the limitations of previous auricular reconstruction methods. Further studies are required to achieve a functional and stable substitute for auricular cartilage and to extend the clinical use of the 3D-printed construct. Additionally, the ethical and legal issues regarding the transplantation of 3D-printed constructs and cell culture technologies using human stem cells remain to be solved. FIGURE 1. The "segmentation" procedure. The contralateral unaffected ear was extracted from other tissue using the "segmentation" procedure.

show abstract

Section: Resultsmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ideal scaffold design for total ear reconstruction using a three‐dimensional printing technique

Jung

Kim

et al. 2018

J Biomed Mater Res

View full text Add to dashboard Cite

show abstract

“…PCL has been widely used for drug delivery devices and in the tissue engineering field because it is biocompatible and slowly degrades in the body . The long‐term biodegradability of PCL mesh can resist deformations because of contractions of the skin and scars that occur during the healing process . The mesh is completely absorbed after several years, which is helpful for avoiding skin thinning and ulcerations from excessive local mechanical pressure .…”

Section: Discussionmentioning

confidence: 99%

Surgical outcomes and complications of septal extension graft supported by 3D printed polycaprolactone plate

Kim¹,

Choi

2019

The Laryngoscope

View full text Add to dashboard Cite

Background Tip plasty using a septal extension graft (SEG) is useful in the Asian population. However, complications such as decreased tip projection, infection, or deviation are noted post‐surgery, and additional support using an SEG is often necessary. We aimed to transplant an additional 3D printed polycaprolactone (PCL) graft to the tip plasty using the SEG to reinforce the SEG. Methods The study included 43 patients (20 males and 23 females; mean age, 28.7 years; range, 17–58 years) who received rhinoplasties using the SEG method combined with a 3D printed PCL graft from November 2016 to August 2017. The mean observation period was 14.8 months (range, 12–20 months). Results Twenty‐six patients rated their satisfaction level as excellent, 13 rated good, 3 rated fair, and 1 rated poor. In total, 28 patients did not exhibit tip drooping at the 1‐year follow‐up; 13 patients demonstrated mild to moderate tip drooping, and 2 patients demonstrated severe tip drooping. Thirty‐one patients demonstrated “stiffness” of the nasal tip, of which 11 patients reported discomfort, and 20 patients reported none; two patients demonstrated deviation of the tip. Conclusion Although the 3D‐printed PCL graft provided support, biocompatibility, and manipulability, care is required to prevent complications. Level of Evidence 4 Laryngoscope, 130:1680–1685, 2020

show abstract

Clinical Application of 3-Dimensional Printing Technology for Patients With Nasal Septal Deformities

Kim

Shim

et al. 2018

JAMA Otolaryngol Head Neck Surg

Self Cite

View full text Add to dashboard Cite

IMPORTANCE Studies have shown the controllability and porosity of polycaprolactone as well as the use of 3-dimensional (3-D) printing for nasal reconstruction in animal models. The utility of polycaprolactone with 3-D technology in nasal cartilaginous framework reconstruction in humans remains unknown. OBJECTIVE To investigate the safety and efficacy of 3-D printed, bioresorbable polycaprolactone nasal implants. DESIGN, SETTING, AND PARTICIPANTS This multicenter clinical trial comprised 20 patients with caudal septal deviations who underwent septoplasty, which used a 3-D printed polycaprolactone mesh, at 2 centers in South Korea. Patients were included if they were aged 18 to 74 years and had nasal septal deviations, Nasal Obstruction Symptom Evaluation scores greater than 20, and persistent nasal obstructions. Twenty-two patients met the inclusion criteria, but 2 patients were excluded before the operation. The study was conducted from July 1, 2016, to June 30, 2017. MAIN OUTCOMES AND MEASURES The change in total Nasal Obstruction Symptom Evaluation score between the preoperative examination and the week 12 postoperative examination was the primary outcome. Changes in bilateral nasal cavity minimum cross-sectional area and volume on acoustic rhinometry at weeks 4 and 12 after the operation as well as changes in the nasal cavity cross-sectional area at the osteomeatal unit and nasal septum angle in the paranasal sinus on computed tomography after week 12 were among the secondary outcomes. RESULTS Of the 20 patients included in the study, 4 (20%) were female, 16 (80%) were male, with a mean (SD) age of 34.95 (11.96) years. The preoperative and week 12 postoperative results revealed significant changes in the minimal cross-sectional areas on acoustic rhinometry (0.

show abstract

New application of three‐dimensional printing biomaterial in nasal reconstruction

Abstract: NA. Laryngoscope, 127:1036-1043, 2017.

Cited by 55 publications

References 25 publications

Ideal scaffold design for total ear reconstruction using a three‐dimensional printing technique

Ideal scaffold design for total ear reconstruction using a three‐dimensional printing technique

Surgical outcomes and complications of septal extension graft supported by 3D printed polycaprolactone plate

Clinical Application of 3-Dimensional Printing Technology for Patients With Nasal Septal Deformities

Contact Info

Product

Resources

About