New Application of 18F-Fluoride PET for the Detection of Bone Remodeling in Early-Stage Osteoarthritis of the Hip

Kobayashi, Naomi; Inaba, Yutaka; Tateishi, Ukihide; Yukizawa, Yohei; Ike, Hiroyuki; Inoue, Tomio; Saito, T.

doi:10.1097/rlu.0b013e31828d30c0

Cited by 52 publications

(69 citation statements)

References 25 publications

(30 reference statements)

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“…However, PET provides an alternative means that can elucidate molecular and cellular changes of the affected joints. Because changes in bone metabolism are present long before clear morphological signs, NaF-as well as FDG-PET can sooner identify and characterize early-stage OA, allowing for quicker treatment and closer monitoring of disease progression [58,59]. Furthermore, NaF demonstrates higher accuracy and sensitivity than 99m Tc-MDP and can reliably identify areas of high mechanical stress [60,61].…”

Section: Rheumatic Diseasesmentioning

confidence: 97%

Evolving Role of Molecular Imaging with 18F-Sodium Fluoride PET as a Biomarker for Calcium Metabolism

Raynor

Houshmand

Gholami

et al. 2016

Curr Osteoporos Rep

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(18)F-sodium fluoride (NaF) as an imaging tracer portrays calcium metabolic activity either in the osseous structures or in soft tissue. Currently, clinical use of NaF-PET is confined to detecting metastasis to the bone, but this approach reveals indirect evidence for disease activity and will have limited use in the future in favor of more direct approaches that visualize cancer cells in the read marrow where they reside. This has proven to be the case with FDG-PET imaging in most cancers. However, a variety of studies support the application of NaF-PET to assess benign osseous diseases. In particular, bone turnover can be measured from NaF uptake to diagnose osteoporosis. Several studies have evaluated the efficacy of bisphosphonates and their lasting effects as treatment for osteoporosis using bone turnover measured by NaF-PET. Additionally, NaF uptake in vessels tracks calcification in the plaques at the molecular level, which is relevant to coronary artery disease. Also, NaF-PET imaging of diseased joints is able to project disease progression in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Further studies suggest potential use of NaF-PET in domains such as back pain, osteosarcoma, stress-related fracture, and bisphosphonate-induced osteonecrosis of the jaw. The critical role of NaF-PET in disease detection and characterization of many musculoskeletal disorders has been clearly demonstrated in the literature, and these methods will become more widespread in the future. The data from PET imaging are quantitative in nature, and as such, it adds a major dimension to assessing disease activity.

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Section: Rheumatic Diseasesmentioning

confidence: 97%

Evolving Role of Molecular Imaging with 18F-Sodium Fluoride PET as a Biomarker for Calcium Metabolism

Raynor

Houshmand

Gholami

et al. 2016

Curr Osteoporos Rep

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show abstract

“…High 18 F-NaF uptake has often been observed in degenerative and arthritic knees during evaluation of osseous metastatic disease. 18 F-NaF PET may also be useful in the detection of bone remodeling in early stage OA of the temporomandibular and hip joints (17,66). SUV max was significantly higher in hip joints with an abnormal finding in bone on MRI (67).…”

Section: Osteoarthritis (Oa)mentioning

confidence: 98%

“…F-NaF uptake on PET images are interpreted as processes that increase exposure of the surface of bone and provide a higher availability of binding sites, such as osteolytic and osteoblastic processes (17).…”

mentioning

confidence: 99%

Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease

Kogan

Fan

Gold

2016

Quant. Imaging Med. Surg.

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Early detection of musculoskeletal disease leads to improved therapies and patient outcomes, and would benefit greatly from imaging at the cellular and molecular level. As it becomes clear that assessment of multiple tissues and functional processes are often necessary to study the complex pathogenesis of musculoskeletal disorders, the role of multi-modality molecular imaging becomes increasingly important.New positron emission tomography-magnetic resonance imaging (PET-MRI) systems offer to combine high-resolution MRI with simultaneous molecular information from PET to study the multifaceted processes involved in numerous musculoskeletal disorders. In this article, we aim to outline the potential clinical utility of hybrid PET-MRI to these non-oncologic musculoskeletal diseases. We summarize current applications of PET molecular imaging in osteoarthritis (OA), rheumatoid arthritis (RA), metabolic bone diseases and neuropathic peripheral pain. Advanced MRI approaches that reveal biochemical and functional information offer complementary assessment in soft tissues. Additionally, we discuss technical considerations for hybrid PET-MR imaging including MR attenuation correction, workflow, radiation dose, and quantification.

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“…Kobayashi et al have demonstrated that an increased uptake of 18 F-Fluoride as a bone-imaging tracer represents early abnormalities in the subchondral bone, found prior to radiographic JSN [91]. The same group has further compared the diagnostic value of PET with MRI and radiography in early hip OA, and found that most (96%) of the MRI-positive joints were also PET positive (Fig.…”

Section: Nuclear Medicine -Spect and Petmentioning

confidence: 99%

Imaging of osteoarthritis (OA): What is new?

Mathiessen

Cimmino

Hammer

et al. 2016

Best Practice & Research Clinical Rheumatology

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New Application of 18F-Fluoride PET for the Detection of Bone Remodeling in Early-Stage Osteoarthritis of the Hip

Abstract: 18F-fluoride PET has great potential as an imaging method for diagnosing early-stage OA without any marked radiographic changes.

Cited by 52 publications

References 25 publications

Evolving Role of Molecular Imaging with 18F-Sodium Fluoride PET as a Biomarker for Calcium Metabolism

Evolving Role of Molecular Imaging with 18F-Sodium Fluoride PET as a Biomarker for Calcium Metabolism

Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease

Imaging of osteoarthritis (OA): What is new?

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