New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates

Kurmaz, S. V.; Фадеева, Н. В.; Fedorov, B. S.; Козуб, Г. И.; Emel’yanova, N. S.; Kurmaz, V. A.; Manzhos, R. A.; Balakina, Anastasya A.; Terentyev, A. A.

doi:10.1016/j.mencom.2020.01.007

Cited by 20 publications

(12 citation statements)

References 23 publications

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“…Similar behavior has been observed for the electroreduction of inclusive complexes of RB with cyclodextrines on mercury [48,49] and GC [43] electrodes whereby their reduction potentials shift, resulting in a lower E [48,49] and reduced heights, i.e., the I of the peaks decreases [43] with respect to RB. We have previously observed the considerable differences in electrochemical behavior between initial forms of depolarizers and those encapsulated into such copolymers, e.g., for the cases of zinc tetraphenylporphyrinate [51,52] and various complexes of Pt(IV) [53,54]. Thus, the experimental data indicate the interaction of RB molecules with a VP copolymer.…”

Section: Quantum Chemical Modeling the Structure Of H-complex Of Rb With Vp Monomer And Vp-vp-vp Site Of The Copolymermentioning

confidence: 90%

Mesoporous Networks of N-Vinylpyrrolidone with (di)Methacrylates as Precursors of Ecological Molecular Imprinted Polymers

et al. 2021

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Mesoporous polymer networks were prepared via the cross-linking radical copolymerization of non-toxic hydrophilic N-vinylpyrrolidone (VP) with triethylene glycol dimethacrylate (TEGDM) and poly(ethylene glycol) methyl ester methacrylate (PEGMMA) in bulk, using appropriate soluble and thermodynamically compatible macromolecular additives with a branched structure as porogens. The branched copolymers of various monomer compositions were obtained by radical copolymerization in toluene, controlled by 1-decanethiol, and these materials were characterized by a wide set of physical chemical methods. The specific surface areas and surface morphology of the polymer networks were determined by nitrogen low-temperature adsorption or Rose Bengal (RB) sorption, depending on the copolymer compositions and scanning electron microscopy. The electrochemical properties of RB before and after its encapsulation into a branched VP copolymer were studied on a glassy carbon electrode and the interaction between these substances was observed. Quantum chemical modeling of RB-VP or RB-copolymer complexes has been carried out and sufficiently strong hydrogen bonds were found in these systems. The experimental and modeling data demonstrate the high potency of such mesoporous polymer networks as precursors of molecularly imprinted polymers for the recognition of fluorescent dyes as nanomarkers for biomedical practice.

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Section: Quantum Chemical Modeling the Structure Of H-complex Of Rb With Vp Monomer And Vp-vp-vp Site Of The Copolymermentioning

confidence: 90%

Mesoporous Networks of N-Vinylpyrrolidone with (di)Methacrylates as Precursors of Ecological Molecular Imprinted Polymers

et al. 2021

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Section: Electrochemical Behavior Of Free and Bound Rb In Aqueous Sol...mentioning

confidence: 99%

Mesoporous Networks of N-Vinylpyrrolidone with (di) Methacrylates as Efficient Precursors of Ecological Molecular Imprinted Polymers

Kurmaz¹,

Kurochkin²,

Knerelman³

et al. 2021

Statistical Inference for Ergodic Algorithmic Model (EAM), Applied to Hydrophobic Hydration Processes

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“…Unlike traditional PVP, they are characterized by: (i) amphiphilicity, which is easy to control due to the monomer composition and the comonomer nature; (ii) the ability of copolymers of some composition to respond to external conditions (temperature and pH); (iii) the ability of hydrolysis in acidic and alkaline media along C-O bonds of dimethacrylate units; (iv) sufficiently small size of individual macromolecules and their aggregates in water will facilitate their efficient cellular and tissue uptake. Nanosized systems of metformin as a wellknown antidiabetic agent [43], lipophilic organic complexes of platinum(IV) with antitumor activity [44,45] and zinc tetraphenylporphyrinate as a means of intracellular accumulation visualizing [42] were obtained on their basis. The high biocompatibility of polymer carriers and their ability to penetrate into HeLa cells have been demonstrated in vitro, which indicates that the developed delivery materials are promising for the intracellular delivery of BAC.…”

Section: Introductionmentioning

confidence: 99%

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

et al. 2022

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Nanosized systems of DOX with antitumor activity on the base of micelle-like particles of amphiphilic thermosensitive copolymers of N-vinylpyrrolidone (VP) with triethylene glycol dimethacrylate (TEGDM), and N-vinylpyrrolidone and methacrylic acid (MAA) with TEGDM were explored. They were investigated in aqueous solutions by electron absorption spectroscopy, dynamic light scattering and cyclic voltammetry. Experimental data and quantum-chemical modeling indicated the formation of a hydrogen bond between oxygen-containing groups of monomer units of the copolymers and H-atoms of OH and NH2 groups of DOX; the energies and H-bond lengths in the considered structures were calculated. A simulation of TDDFT spectra of DOX and its complexes with the VP and TEGDM units was carried out. Electrochemical studies in PBS have demonstrated that the oxidation of encapsulated DOX appeared to be easier than that of the free one, and its reduction was somewhat more difficult. The cytotoxicity of VP-TEGDM copolymer compositions containing 1, 5 and 15 wt% DOX was studied in vitro on HeLa cells, and the values of IC50 doses were determined at 24 and 72 h of exposure. The copolymer compositions containing 5 and 15 wt% DOX accumulated actively in cell nuclei and did not cause visual changes in cell morphology.

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New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates

Cited by 20 publications

References 23 publications

Mesoporous Networks of N-Vinylpyrrolidone with (di)Methacrylates as Precursors of Ecological Molecular Imprinted Polymers

Mesoporous Networks of N-Vinylpyrrolidone with (di)Methacrylates as Precursors of Ecological Molecular Imprinted Polymers

Mesoporous Networks of N-Vinylpyrrolidone with (di) Methacrylates as Efficient Precursors of Ecological Molecular Imprinted Polymers

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

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