New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis

Gotsbacher, Michael P.; Karuso, Peter

doi:10.3390/md13031389

Cited by 29 publications

(26 citation statements)

References 57 publications

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“…The EADP structure has been found in a number of compounds including the moloka'iamines [26], ceratinamines [27], purpurealidines [28] and purealidines [29], that have been isolated from the Verongidae sponges. This compound class has been found to possess a wide range of bioactivities, including anti-fouling [30], anti-microbial [31], acetylcholinesterase (AChE) inhibition [32], apolipoprotein E (ApoE) modulating activity [33], anti-HIV [34] and inhibition of the histamine subtype 3 (H 3 ) receptor [35]. It is interesting to note that the H 3 receptor, ApoE and AChE have all been identified as potential targets for the treatment of various neurodegenerative diseases [36,37].…”

Section: Discussionmentioning

confidence: 99%

Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge

Jennings

Ahmed

Munn

et al. 2018

Prion

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One of the major medical challenges of the twenty-first century is the treatment of incurable and fatal neurodegenerative disorders caused by misfolded prion proteins. Since the discovery of these diseases a number of studies have been conducted to identify small molecules for their treatment, however to date no curative treatment is available. These studies can be highly expensive and time consuming, but more recent experimental approaches indicate a significant application for yeast prions in these studies. We therefore used yeast prions to optimize previous high-throughput methods for the cheaper, easier and more rapid screening of natural extracts. Through this approach we aimed to identify natural yeast-prion inhibitors that could be useful in the development of novel treatment strategies for neurodegenerative disorders. We screened 500 marine invertebrate extracts from temperate waters in Australia allowing the identification of yeast-prion inhibiting extracts. Through the bioassay-driven chemical investigation of an active Suberites sponge extract, a group of bromotyrosine derivatives were identified as potent yeast-prion inhibitors. This study outlines the importance of natural products and yeast prions as a first-stage screen for the identification of new chemically diverse and bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge

Jennings

Ahmed

Munn

et al. 2018

Prion

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“…The compound was a simple bromotyrosine derivative with four bromines (m/z 698 (1), 700 (4), 702 (6), 704 (4), 706 (1)) and was consistent with a molecular formula C 21 H 23 Br 4 N 3 O 4 . These data suggest the compound was aplysamine 4 [73] or aplysamine 8 [74].…”

Section: Isolation Of Chitinous Skeleton From the Sponge And Identifimentioning

confidence: 91%

Naturally Prefabricated Marine Biomaterials: Isolation and Applications of Flat Chitinous 3D Scaffolds from Ianthella labyrinthus (Demospongiae: Verongiida)

Schubert

Binnewerg

Voronkina

et al. 2019

IJMS

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Marine sponges remain representative of a unique source of renewable biological materials. The demosponges of the family Ianthellidae possess chitin-based skeletons with high biomimetic potential. These three-dimensional (3D) constructs can potentially be used in tissue engineering and regenerative medicine. In this study, we focus our attention, for the first time, on the marine sponge Ianthella labyrinthus Bergquist & Kelly-Borges, 1995 (Demospongiae: Verongida: Ianthellidae) as a novel potential source of naturally prestructured bandage-like 3D scaffolds which can be isolated simultaneously with biologically active bromotyrosines. Specifically, translucent and elastic flat chitinous scaffolds have been obtained after bromotyrosine extraction and chemical treatments of the sponge skeleton with alternate alkaline and acidic solutions. For the first time, cardiomyocytes differentiated from human induced pluripotent stem cells (iPSC-CMs) have been used to test the suitability of I. labyrinthus chitinous skeleton as ready-to-use scaffold for their cell culture. Results reveal a comparable attachment and growth on isolated chitin-skeleton, compared to scaffolds coated with extracellular matrix mimetic Geltrex®. Thus, the natural, unmodified I. labyrinthus cleaned sponge skeleton can be used to culture iPSC-CMs and 3D tissue engineering. In addition, I. labyrinthus chitin-based scaffolds demonstrate strong and efficient capability to absorb blood deep into the microtubes due to their excellent capillary effect. These findings are suggestive of the future development of new sponge chitin-based absorbable hemostats as alternatives to already well recognized cellulose-based fabrics.

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“…(MIC = 6.25-25 µg/mL) [129]; the antimicrobial peptide isolated from the mucus of the hagfish Myxine glutinosa and several structural analogs (MICs = 1.2-50 µM) [130]; bromopyrrole alkaloids agelamadins C-E (IC 50 = 32 µg/mL) from the Okinawan marine sponge Agelas sp. [131]; a new indole diterpenoid from the fungus Aspergillus flavus (MIC = 20.5 µM), isolated from the Chinese prawn Penaeus vannamei [132]; two new bromopyrrole alkaloids isolated from the Okinawan sponge Agelas sp., namely 2-debromomonagelamide U and 2-debromomukanadin G (MIC=32 µg/mL) [133]; seven known and one new sesquiterpene named epoxysubergorgic acid isolated from the Chinese gorgonian coral S. suberosa (MIC>8 µg/mL) [134]; a new bromotyrosine alkaloid aplysamine 8 (MIC=31 µg/mL) from an Australian marine sponge Pseudoceratina purpurea [135], alternariol derivatives (MIC = 50 µg/disk) from the endophytic fungus Alternaria alternata isolated from the Red sea soft coral Litophyton arboretum [136]; new polyketides amphidins C-F (MIC = 16 and 32 µg/mL), isolated from the culture broth of dinoflagellate Amphidinium sp. […”

Section: Antibacterial Activitymentioning

confidence: 99%

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

et al. 2019

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The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

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New Antimicrobial Bromotyrosine Analogues from the Sponge Pseudoceratina purpurea and Its Predator Tylodina corticalis

Cited by 29 publications

References 57 publications

Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge

Yeast-based screening of natural product extracts results in the identification of prion inhibitors from a marine sponge

Naturally Prefabricated Marine Biomaterials: Isolation and Applications of Flat Chitinous 3D Scaffolds from Ianthella labyrinthus (Demospongiae: Verongiida)

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

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