New antihistamines – perspectives in the treatment of some allergic and inflammatory disorders

Tatarkiewicz, Jan; Rzodkiewicz, Przemysław; Żochowska, Małgorzata; Staniszewska, Anna; Bujalska‐Zadrożny, Magdalena

doi:10.5114/aoms.2017.68534

Cited by 23 publications

(23 citation statements)

References 159 publications

(280 reference statements)

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“…Therefore, antihistamine drugs are used as therapeutic drugs for AR worldwide [ 1 , 3 ]. Four histamine receptors, the H1, H2, H3, and H4 receptors, have been identified, and the antihistamine drugs for AR treatment are targeted to the H1 receptor (H1R) [ 4 ]. Antiallergic drug research and development efforts are now targeting the H4 receptor (H4R), since H4R is predominantly expressed on immune cells, such as mast cells, basophils, T cells, and eosinophils [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Iwasaki¹,

Shimizu²,

Oikawa³

et al. 2021

PLoS ONE

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Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine. Moreover, recent studies have revealed that macrophages, especially alternatively activated macrophages (M2) induced by T helper 2 (Th2) cytokines, such as interleukin (IL)-4 and IL-13, participate in the pathogenesis of allergic diseases. The major source of Th2 cytokines is antigen-specific Th2 cells. To elucidate the relationship between histamine, macrophages, and Th2 cells in allergic inflammation, we established a macrophage-Th2 cell co-culture model in vitro and an antigen-specific Th2 cell transfer mouse model of rhinitis. In vitro analyses indicated that macrophages produce histamine by interacting with antigen-specific Th2 cells through the antigen. Furthermore, Th2 cells and macrophages cooperatively elicited rhinitis in the mouse model. We determined that histamine induces Th2- and macrophage-elicited sneezing responses through H1 receptor signaling, whereas it induces nasal eosinophil infiltrations through H4 receptor signaling. Collectively, these results indicate a novel histamine production mechanism by macrophages, in which Th2 cells and macrophages cooperatively induce nasal allergic inflammation through histamine signaling.

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Section: Introductionmentioning

confidence: 99%

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Iwasaki¹,

Shimizu²,

Oikawa³

et al. 2021

PLoS ONE

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“…H4 receptors are found on cells of the immune system, in the gastrointestinal tract, in the CNS, and on afferent neurons with primary sensors. The action of histamine on H4 receptors induces chemotaxis, cytokine secretion, and upregulation of adhesion molecules …”

Section: Introductionmentioning

confidence: 99%

“…H1 antihistamines are widely used in pediatric patients to treat histamine‐dependent symptoms. It is possible to distinguish first‐ and second‐generation antihistamines; pharmacological effects and therapeutic applications are similar, but second‐generation antihistamines have fewer adverse effects because they are more selective for peripheral H1 receptors . Some second‐generation antihistamines have also some important additional anti‐inflammatory effects that occur by a decrease in production of cytokines and release of other mediators by mastocytes and basophils; in recruitment of eosinophils in the late phase of allergic reactions; and in expression of membrane receptors in nasal epithelial cells and vascular endothelium, mainly concerning the adhesion molecule ICAM‐1, which favors leukocyte migration from the blood to the respiratory mucosa and constitutes the main receptor for rhinovirus implicated in asthma exacerbation…”

Section: Introductionmentioning

confidence: 99%

Antihistamines: ABC for the pediatricians

Parisi

Licari

Papale

et al. 2020

Pediatric Allergy Immunology

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Antihistamines are currently one of the most commonly administered drugs in children. They are used to treat symptoms that depend on histamine release, namely allergic diseases, such as rhinitis, asthma, urticaria, and anaphylaxis. It is possible to distinguish first-and second-generation antihistamines. Pharmacological effects and therapeutic indications are similar, but second-generation antihistamines have fewer adverse effects because they are more selective for peripheral H1 receptors.Although they have been on the market for several years, there are still many adverse effects linked to the antihistamine safety profile, especially in the first years of life.Thus, many antihistamines are prescribed off-label, especially in children younger than 2 years of age, which is the age-group where most of the data on drug safety are lacking and many antihistamines are not recommended. This article aims to provide a practical update on the use of antihistamines in children.

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Section: Introductionmentioning

confidence: 99%

“…H1-antihistamines are widely used in patients to treat symptoms that are secondary to histamine release, which is typical of certain allergic conditions. It is possible to distinguish first and second-generation antihistamines; pharmacological effects and therapeutic applications are similar, but second-generation antihistamines have fewer adverse effects because they are more selective for peripheral H1 receptors [1].…”

Section: Introductionmentioning

confidence: 99%

Focus on the cetirizine use in clinical practice: a reappraisal 30 years later

Corsico

Leonardi

Licari

et al. 2019

Multidiscip Respir Med

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Antihistamines are currently one of the most commonly administered categories of drugs. They are used to treat symptoms that are secondary to histamine release, which is typical of certain allergic conditions, including rhinitis, conjunctivitis, asthma, urticaria, and anaphylaxis. Cetirizine belongs to the second-generation family, so, it is very selective for peripheral H1 receptors, is potent and quickly relieves symptoms, exerts additional anti-allergic/anti-inflammatory effects, and is usually well-tolerated. It has been marketed 30 years ago. In these years, a remarkable body of evidence has been built. The current review provides a practical update on the use of cetirizine in clinical practice.

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New antihistamines – perspectives in the treatment of some allergic and inflammatory disorders

Cited by 23 publications

References 159 publications

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling

Antihistamines: ABC for the pediatricians

Focus on the cetirizine use in clinical practice: a reappraisal 30 years later

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