New antiherpes drugs in development

Js, Cameron

doi:10.1002/rmv.1980030406

Cited by 10 publications

(2 citation statements)

References 63 publications

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“…During primary and recurrent infection the virus causes vesicular lesions of the skin and mucosa. Infection is generally limited to the oropharynx but may involve the eyes and the genitalia (Whitley, 1985;Cameron, 1993).…”

Section: Human Herpesvirusesmentioning

confidence: 99%

“…The clinical pathologies associated with HSV-1 and herpes simplex virus type 2 (HSV-2) are not strictly separated (Nahmias et al, 1991). However, HSV-2 is transmitted sexually, although infection may occur at birth (Whitley, 1985;Cameron, 1993), and lesions are localised to the mucous membranes and skin of the genitals. HSV-2 reactivation usually occurs more frequently than that of HSV-1 (Timbury, 1991;Whitley, 1990).…”

Section: Human Herpesvirusesmentioning

confidence: 99%

See 1 more Smart Citation

The DNA Sequence of the RK Strain of Human Herpesvirus 7

Ag¹,

Rapaport

Avidor

et al. 1998

Virology

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The complete DNA sequence of human herpesvirus-7 (HHV-7) strain RK was determined following direct cloning of virion DNA fragments into a sequencing vector. The sequence was compared with the previously published complete sequences of HHV-7 strain JI and human herpesvirus-6 (HHV-6) strain U1102. Despite a very close relationship between the two HHV-7 strains, differences are apparent in regions containing tandem reiterations, particularly in the "telomeric" reiterations located near the termini of the large direct repeat at the genome ends, and in a total of 179 additional positions distributed throughout the genome (i.e., about one nucleotide difference per kbp). This extent of divergence implies that the two strains arose from an ancestral virus several thousands of years ago. Differences that affect coding potential do not cluster in particular protein-coding regions, indicating that specific HHV-7 genes have not been measurably subject to unusual evolutionary pressures since divergence. Reassessments of genetic content indicated that the HHV-7 genome contains 84 different genes, whereas the HHV-6 genome contains 85. All HHV-7 genes but 1 have direct HHV-6 counterparts, and all but 2 HHV-6 genes have HHV-7 homologues. Sequence comparisons between HHV-7 and HHV-6 provided evidence that the protein-coding regions of 11 genes are expressed by splicing.

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Section: Human Herpesvirusesmentioning

confidence: 99%

Section: Human Herpesvirusesmentioning

confidence: 99%