New antibacterial targets: Regulation of quorum sensing and secretory systems in zoonotic bacteria

Shen, Yamin; Gao, Shuji; Fan, Qingying; Zuo, Jing; Wang, Yuxin; Li, Yang; Wang, Yang

doi:10.1016/j.micres.2023.127436

Cited by 5 publications

(2 citation statements)

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“…This has led to serotype 2 being historically considered the most prevalent and virulent [ 50 ]. QS plays a vital role in bacterial behavioral regulation, with AI-2 QS, which is based on AI-2 signalling molecules, acknowledged universally as a “language” for bacterial communication [ 13 ]. However, it remains uncertain whether AI-2 QS solely activates the methyl cycle or participates in other bacterial metabolic activities.…”

Section: Discussionmentioning

confidence: 99%

“…Quorum sensing (QS) represents a cell-to-cell communication process occurring both within and among bacterial species [ 12 ]. QS can be categorized into three major groups: (i) LuxI/R-type QS in gram-negative bacteria, (ii) oligopeptide two-component QS in gram-positive bacteria, and (iii) the interspecies communication system known as LuxS-mediated AI-2 QS found in various microbial communities [ 13 ]. Our research has established the global regulatory impact of AI-2 QS on S. suis virulence [ 14 – 16 ], although the specific regulatory pathway involved remains elusive.…”

Section: Introductionmentioning

confidence: 99%

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AI-2 quorum sensing-induced galactose metabolism activation in Streptococcus suis enhances capsular polysaccharide-associated virulence

Gao,

Mao,

Yuan

et al. 2024

Vet Res

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Bacteria utilize intercellular communication to orchestrate essential cellular processes, adapt to environmental changes, develop antibiotic tolerance, and enhance virulence. This communication, known as quorum sensing (QS), is mediated by the exchange of small signalling molecules called autoinducers. AI-2 QS, regulated by the metabolic enzyme LuxS (S-ribosylhomocysteine lyase), acts as a universal intercellular communication mechanism across gram-positive and gram-negative bacteria and is crucial for diverse bacterial processes. In this study, we demonstrated that in Streptococcus suis (S. suis), a notable zoonotic pathogen, AI-2 QS enhances galactose utilization, upregulates the Leloir pathway for capsular polysaccharide (CPS) precursor production, and boosts CPS synthesis, leading to increased resistance to macrophage phagocytosis. Additionally, our molecular docking and dynamics simulations suggest that, similar to S. pneumoniae, FruA, a fructose-specific phosphoenolpyruvate phosphotransferase system prevalent in gram-positive pathogens, may also function as an AI-2 membrane surface receptor in S. suis. In conclusion, our study demonstrated the significance of AI-2 in the synthesis of galactose metabolism-dependent CPS in S. suis. Additionally, we conducted a preliminary analysis of the potential role of FruA as a membrane surface receptor for S. suis AI-2.

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Section: Discussionmentioning

confidence: 99%