New Antiadhesive Hydrophobic Polysiloxanes

Nowacka, Maria; Rygała, Anna; Kręgiel, Dorota; Kowalewska, Anna

doi:10.3390/molecules26040814

Cited by 9 publications

(8 citation statements)

References 69 publications

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“…The best antiadhesive action was detected for the CuHABH complex for both bacterial strains. This was confirmed in microscopic observations using fluorescence microscopy after DAPI staining [82] (Figure 9). The highest levels of RLU corresponding to organic matter and ATP were recorded for the DMSO solution.…”

Section: Antibiofilm Activitysupporting

confidence: 68%

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From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects

et al. 2022

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Microorganisms are able to give rise to biofilm formation on food matrixes and along food industry infrastructures or medical equipment. This growth may be reduced by the application of molecules preventing bacterial adhesion on these surfaces. A new Schiff base ligand, derivative of hesperetin, HABH (2-amino-N′-(2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene)benzohydrazide), and its copper complex, CuHABH [CuLH2(OAc)], were designed, synthesized and analyzed in terms of their structure and physicochemical properties, and tested as antibacterial agents. Their structures both in a solid state and in solution were established using several methods: FT-IR, 1H NMR, 13C NMR, UV-Vis, FAB MS, EPR, ESI-MS and potentiometry. Coordination binding of the copper(II) complex dominating at the physiological pH region in the solution was found to be the same as that detected in the solid state. Furthermore, the interaction between the HABH and CuHABH with calf-thymus DNA (CT-DNA) were investigated. These interactions were tracked by UV-Vis, CD (circular dichroism) and spectrofluorimetry. The results indicate a stronger interaction of the CuHABH with the CT-DNA than the HABH. It can be assumed that the nature of the interactions is of the intercalating type, but in the high concentration range, the complex can bind to the DNA externally to phosphate residues or to a minor/major groove. The prepared compounds possess antibacterial and antibiofilm activities against Gram-positive and Gram-negative bacteria. Their antagonistic activity depends on the factor-strain test system. The glass was selected as a model surface for the experiments on antibiofilm activity. The adhesion of bacterial cells to the glass surface in the presence of the compounds was traced by luminometry and the best antiadhesive action against both bacterial strains was detected for the CuHABH complex. This molecule may play a crucial role in disrupting exopolymers (DNA/proteins) in biofilm formation and can be used to prevent bacterial adhesion especially on glass equipment.

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Section: Antibiofilm Activitysupporting

confidence: 68%

Section: Antibiofilm Activitysupporting

confidence: 68%

From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects

et al. 2022

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“…These reactive groups interact via hydrogen bonding with other functional groups, allowing them to bond with the glass surface [ 26 , 27 , 28 ]. Glass as a carrier is less colonized than hydrophobic surfaces, so the colonization effect is usually obtained by strongly adhering microbial cells [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade

et al. 2022

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Pulcherrimin is a secondary metabolite of yeasts belonging to the Metschnikowia pulcherrima clade, and pulcherrimin formation is responsible for the antimicrobial action of its producers. Understanding the environmental function of this metabolite can provide insight into various microbial interactions and enables the efficient development of new effective bioproducts and methods. In this study, we evaluated the antimicrobial and antiadhesive action of yeast pulcherrimin, as well as its protective properties under selected stressful conditions. Classical microbiological plate methods, microscopy, and physico-chemical testing were used. The results show that pure pulcherrimin does not have antimicrobial properties, but its unique hydrophilic nature may hinder the adhesion of hydrophilic bacterial cells to abiotic surfaces. Pulcherrimin also proved to be a good cell protectant against UV–C radiation at both high and low temperatures.

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“…Poly(dimethylsiloxane), e. g PDMS-based polymers, commonly known as silicones, are not inherently antibacterial. Additives such as catalysts, including platinum nanoparticles 6 , and other low molecular weight species incorporated between polymer chains or grafted onto the polymer backbone may give silicone antibacterial activity [7][8][9] . Low surface tension and, therefore, high hydrophobicity is reported to be one of the primary reasons PDMS is prone to protein adsorption and bacterial adhesion 10 .…”

Section: Introductionmentioning

confidence: 99%

Elastomeric silicone foam - an antibacterial environment or a new habitat for bacteria?

Rebane

Priks

Levin

et al. 2023

Preprint

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Silicone is often used in environments where water repellency is an advantage. Contact with water promotes the adhesion of microorganisms and biofilm formation. Depending on the application, this may increase the possibility of food poisoning and infections, the material's degrading appearance, and the likelihood of manufacturing defects. The prevention of microbial adhesion and biofilm formation is also essential for silicone-based elastomeric foams, which are used in direct contact with human bodies but are often difficult to clean. In this study, the microbial attachment in and the retention from the pores of silicone foams of different compositions is described and compared to those of commonly used polyurethane foams. The growth of the gram-negative Escherichia coli in the pores and their leaching during wash cycles is characterised by bacterial growth/inhibition, adhesion assay, and SEM imaging. The structural and surface properties of the materials are compared. Despite using common antibacterial additives, we have found that non-soluble particles stay isolated in the silicone elastomer layer and, therefore, do not possess antibacterial activity. Water-soluble tannic acid dissolves into the medium and seems to aid in inhibiting planktonic bacterial growth, indicating that tannic acid is available on the surface of the SIFs to some extent.

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New Antiadhesive Hydrophobic Polysiloxanes

Cited by 9 publications

References 69 publications

From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects

From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects

Biological Activity of Pulcherrimin from the Meschnikowia pulcherrima Clade

Elastomeric silicone foam - an antibacterial environment or a new habitat for bacteria?

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