New anti-inflammatory steroids from the Formosan soft coral Clavularia viridis

Chang, Chin-Hsiang; Wen, Zhi‐Hong; Wang, Shang‐Kwei; Duh, Chang‐Yih

doi:10.1016/j.steroids.2008.01.007

Cited by 21 publications

(16 citation statements)

References 21 publications

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“…At a concentration of 10 µM, compounds 264 – 275 , 277 – 291 , 293 , 294 , 297 , 303 – 307 and 316 – 320 reduced LPS-induced expression level of iNOS in murine macrophage cells (RAW264.7) [ 21 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 83 , 84 ]. Compounds 265 , 266 , 271 , 275 , 277 , 278 , 280 , 281 , 283 – 286 , 288 , 290 , 291 , 293 and 319 suppressed LPS-induced expression level of COX-2 in murine macrophage cells (RAW264.7) [ 21 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 84 ]. At 10 µg/mL, compounds 321 and 322 inhibited the generation of superoxide anion and the release of elastase by activated human neutrophils [ 73 , 85 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012

et al. 2013

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This review reports details on the natural products isolated from Taiwan soft corals during the period 2008–2012 focusing on their in vitro and/or in vivo anti-inflammatory activities. Chemical structures, names, and literature references are also reported. This review provides useful and specific information on potent anti-inflammatory marine metabolites for future development of immune-modulatory therapeutics.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012

et al. 2013

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“…While the EPA of fish oils inhibited COX-1 more than COX-2 [ 168 ], DCHA was shown to be an effective inhibitor of arachidonic acid induced prostaglandin biosynthesis [ 169 ]. Among the other reports available indicating the role of nutraceuticals in the cyclooxygenase pathway, calcitriol (vitamin D) [ 170 ], several types of flavonoids [ 171 , 172 ], and marine derived steroids from formosan soft coral Clavularia viridis [ 173 ] all have been reported to affect prostaglandin synthesis. Interestingly most of the compounds exhibit antioxidant properties and inhibit both COX-1 and COX-2 [ 161 , 172 ] suggesting a role in cardioprotection.…”

Section: Possible Alternatives To Nsaids For Reduced Cardiovasculmentioning

confidence: 99%

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Ghosh

Alajbegovic

Gomes

2015

Oxidative Medicine and Cellular Longevity

139

106

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.

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“…A large number of other phytosterol compounds were also found in fungi, such as ergosterol and ergosterol acetate. The anti-inflammatory activity of phytosterol compounds from plants was studied, and the anti-inflammatory sterols found in plants were identified in many studies [17,18,19,20]. Phytosterol compounds can reduce the expression of the pro-inflammatory mediators, cyclooxygenase-2 (COX-2) and nitric oxide synthase (iNOS), in LPS-stimulated RAW264.7 macrophages [21,22].…”

Section: Introductionmentioning

confidence: 99%

Phytosterols Suppress Phagocytosis and Inhibit Inflammatory Mediators via ERK Pathway on LPS-Triggered Inflammatory Responses in RAW264.7 Macrophages and the Correlation with Their Structure

Yuan

Zhang

Shen

et al. 2019

Foods

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Phytosterols, found in many commonly consumed foods, exhibit a broad range of physiological activities including anti-inflammatory effects. In this study, the anti-inflammatory effects of ergosterol, β-sitosterol, stigmasterol, campesterol, and ergosterol acetate were investigated in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Results showed that all phytosterol compounds alleviated the inflammatory reaction in LPS-induced macrophage models; cell phagocytosis, nitric oxide (NO) production, release of tumor necrosis factor-α (TNF-α), and expression and activity of pro-inflammatory mediator cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and phosphorylated extracellular signal-regulated protein kinase (p-ERK) were all inhibited. The anti-inflammatory activity of β-sitosterol was higher than stigmasterol and campesterol, which suggests that phytosterols without a double bond on C-22 and with ethyl on C-24 were more effective. However, inconsistent results were observed upon comparison of ergosterol and ergosterol acetate (hydroxy or ester group on C-3), which suggest that additional research is still needed to ascertain the contribution of structure to their anti-inflammatory effects.

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New anti-inflammatory steroids from the Formosan soft coral Clavularia viridis

Cited by 21 publications

References 21 publications

Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012

Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Phytosterols Suppress Phagocytosis and Inhibit Inflammatory Mediators via ERK Pathway on LPS-Triggered Inflammatory Responses in RAW264.7 Macrophages and the Correlation with Their Structure

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