New and Old Therapeutic Options for Luminal Crohn's Disease - An Overview of Current Literature

Abstract

Crohn's Disease (CD) is a chronic inflammatory, relapsing and remitting condition that leads to structural damage of the bowel wall. It can be located in any part of the gastrointestinal tract with associated extra-intestinal manifestations. It varies in severity having many complications resulting in significant morbidity. In the past decade medical management of CD has evolved rapidly and with ongoing research it continues to show promising novel therapies. In this article we aim to give an overview of current literature on old and new therapy options for luminal CD looking at data including their efficacy and safety. With new oral biologic therapies such as the Janus Kinase inhibitor and gut specific targeted therapies developing their place in this ever growing marketplace treatment options for physicians are going to become even more challenging.