New and Known Cyanogenic Glycosides from the Rubiaceae

Rockenbach, Jürgen; Nahrstedt, Adolf

doi:10.1055/s-2006-961200

Cited by 7 publications

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“…Cooper-Driver et al 1977;Fikenscher and Hegnauer 1977;Spencer and Seigler 1983;Maslin et al 1988;Rockenbach and Nahrstedt 1990;Gleadow et al 2003). Amygdalin, which has been isolated from a large number of species, is primarily restricted to the fruits of Rosaceae (Gomez et al 1998;Møller and Seigler 1999;Dicenta et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Cyanogenesis in the Australian tropical rainforest endemic Brombya platynema (Rutaceae): chemical characterisation and polymorphism

Miller

Simon

Woodrow

2006

Functional Plant Biol.

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Abstract. This study examined two aspects of cyanogenesis in Brombya platynema F. Muell. (Rutaceae), a subcanopy tree endemic to tropical rainforest in far north Queensland, Australia. First, cyanogenic glycosides in foliage were fractionated and identified. The rare meta-hydroxylated cyanogenic glycoside, holocalin, was identified as the principal cyanogen, and traces of prunasin and amygdalin were detected. This is the first characterisation of cyanogenic constituents within the genus, and to the authors' knowledge, only the third within the Rutaceae, and the order Rutales. Second, variation in cyanogenic glycoside content within a population of B. platynema in lowland tropical rainforest was quantified. Both qualitative and quantitative polymorphism for cyanogenesis was identified. Interestingly, ∼57% of individuals were considered acyanogenic, with concentrations of cyanogenic glycosides less than 8 µg CN g −1 DW. Among cyanogenic individuals there was substantial quantitative variation in cyanogenic glycoside concentration, which varied from 10.5 to 1285.9 µg CN g −1 DW. This high frequency of acyanogenic individuals is contrasted with the apparent absence of the acyanogenesis among populations of other tropical rainforest tree species. In the high herbivory environment of the tropical rainforest, this frequency of acyanogenesis among cyanogenic tropical tree taxa is unique.

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Section: Discussionmentioning

confidence: 99%

Cyanogenesis in the Australian tropical rainforest endemic Brombya platynema (Rutaceae): chemical characterisation and polymorphism

Miller

Simon

Woodrow

2006

Functional Plant Biol.

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Linking phytochemistry to traditional uses and pharmacology of an underexplored genus – Psydrax: a review

2022

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The genus Psydrax is one of the ethno-medicinally important genera of the Rubiaceae family which has only received a limited scientific attention, despite coming from a pharmacologically and phytochemically important plant family. The genus has found applications in ethnomedical management of diabetes, stomach disorders, inflammations, cardiovascular diseases, epilepsy, wounds, malaria and fever. To unveil knowledge gaps, stimulate research interest and unravel opportunities for drug discovery from the genus Psydrax , we have carried out an extensive review on its traditional applications, phytochemistry and pharmacology for the first time. Literature on these topics was obtained from Google Scholar, Pubmed and ScienceDirect journal articles published from 1788 to September, 2021. Only articles written in English were reviewed. While several species of Pysdrax used in traditional medicine have not been chemically explored for drug discovery, over a hundred secondary metabolites have so far been identified in few species of the genus, and majority of these chemotaxonomic markers are iridoids. Bioactive extracts and some isolated constituents of Psydrax species have shown various in vitro and in vivo pharmacological properties including anti-hyperglycemia, anti-inflammatory, anticonvulsant and antimicrobial, and thus, support some of the ethnomedical uses of the plants. For an evidence-informed application of the genus, Psydrax , in traditional medicine, more ethnobotanical surveys, elaborate in vivo pharmacological assays, in-depth toxicity and holistic phytochemical studies are required to fully exploit more species of the genus prior to future clinical studies. Following documented traditional uses of Psydrax species, the deliberate cultivation of medicinal plants under this genus is recommended for sustainability in medicinal plant utilization.

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Glycosides

Bartnik

Facey

2017

Pharmacognosy

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New and Known Cyanogenic Glycosides from the Rubiaceae

Abstract: Posters Planta Med. 56(1990) 591 GLUCOIBERIN SINIGRIN GLUCOSINALBIN Time (mm) GLUCOERASSICIN Fig. 1 Representative chromatogram of intact, underivatized glucosinolate standard mixture, 1.0 g each.

Cited by 7 publications

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Cyanogenesis in the Australian tropical rainforest endemic Brombya platynema (Rutaceae): chemical characterisation and polymorphism

Cyanogenesis in the Australian tropical rainforest endemic Brombya platynema (Rutaceae): chemical characterisation and polymorphism

Linking phytochemistry to traditional uses and pharmacology of an underexplored genus – Psydrax: a review

Glycosides

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