New and emerging therapies for gout

Crittenden, Daria B.; Kim, Han Na; Fisher, Mark; Goldfarb, David S.; Pillinger, Michael H.

doi:10.4155/cli.11.143

Cited by 2 publications

(2 citation statements)

References 69 publications

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“…34 Given these assertions, it is tempting to consider whether the beneficial effects of the anti-fibrotic agent, tranilast, in diabetic nephropathy, 35,36 may also be partly a consequence of its uricosuric action. 37…”

Section: Uric Acid Uric Acid and Cardiorenal Diseasementioning

confidence: 99%

Sodium–glucose linked transporter-2 inhibitors: potential for renoprotection beyond blood glucose lowering?

Gilbert

2014

Kidney International

100

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The proximal tubule's sodium-glucose linked transporter-2 (SGLT2) accounts for the vast majority of glucose reabsorption by the kidney. Its selective inhibition, accordingly, leads to substantial glycosuria, lowering blood glucose, and facilitating weight loss in individuals with diabetes. During the past year, two SGLT2 inhibitors, canagliflozin and dapagliflozin, have been approved for the treatment of type 2 diabetes. Beyond their anti-hyperglycemic properties, however, this new class of drugs has several other attributes that provide a theoretical basis for kidney protection. Like agents that block the renin-angiotensin system, SGLT2 inhibitors also reduce single-nephron glomerular filtration rate (SNGFR) in the chronically diseased kidney, though by quite different mechanisms. Additional potentially beneficial effects of SGLT2 inhibition include modest reductions in blood pressure and plasma uric acid. Finally, cell culture studies indicate that glucose uptake from the tubular lumen, as well as from the basolateral compartment, can contribute to proximal tubular production of extracellular matrix proteins. Whether such attributes will translate into reducing the progression of chronic kidney disease will require the undertaking of long-term, dedicated studies.

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Section: Uric Acid Uric Acid and Cardiorenal Diseasementioning

confidence: 99%

Sodium–glucose linked transporter-2 inhibitors: potential for renoprotection beyond blood glucose lowering?

Gilbert

2014

Kidney International

100

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“…Our paper is a hybrid: not a review, but it references some academic literature; not a research study, but with development of hypotheses to be tested in sound research designs; not a case study, but with 13 cases presented from which theory can be proposed; not a new approach to clinical assessment or treatment, but with recommendations to consider until empirical research based on its ideas can inform practice. We expand on our version of a sequential, cross-sectional longitudinal case methodology in the accompanying paper (Crittenden, 2023).…”

Section: Methodological Considerationsmentioning

confidence: 99%

Sexual signals and behavior in children: Building hypotheses about the function of sexuality in childhood

Crittenden,

Landini

2023

Human Systems: Therapy, Culture and Attachments

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Increasingly children have been referred for assessment and treatment because they used sexual behavior including “sexually harmful behavior.” Such children are often treated as a source of danger to others rather than as neglected or abandoned children who used sexualized behavior to protect themselves. In this exploratory paper, we present a series of case examples, arranged developmentally from infancy to puberty. All had standardized assessments of attachment from which detailed descriptions of behavior were derived. In addition, we have information about the parents that we used to help explain their behavior. We also review briefly the scientific basis for understanding how smell and touch affect sexualized behavior involving children. We conclude that children’s sexualized behavior and sexualized behavior from parents to young children is usually not sexually motivated. Instead, the behavior appears to serve attachment functions for both children and parents when their needs for protection and comfort have not been met. We note that sexual bonds are formed very rapidly whereas attachment bonds are formed slowly. Under urgent and dangerous conditions, sexuality may make bonds more quickly than slower attachment processes could do, thus providing the advantages of attachment (protection and comfort) quickly. Of course, this short-cut comes at a developmental cost. We close with recommendations for research and for professional practice.

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New and emerging therapies for gout

Cited by 2 publications

References 69 publications

Sodium–glucose linked transporter-2 inhibitors: potential for renoprotection beyond blood glucose lowering?

Sodium–glucose linked transporter-2 inhibitors: potential for renoprotection beyond blood glucose lowering?

Sexual signals and behavior in children: Building hypotheses about the function of sexuality in childhood

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