New and Emerging Techniques in Cartilage Repair: Matrix-Induced Autologous Chondrocyte Implantation

Dunkin, Brad S.; Lattermann, Christian

doi:10.1053/j.otsm.2013.03.003

Cited by 43 publications

(26 citation statements)

References 47 publications

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“…Many variables may influence the clinical outcomes of patients treated with MACI, including age, BMI, chondral defect size, location and mechanism of injury, joint degeneration at the time of surgery, ex vivo chondrocyte culture procedure, preoperative duration of symptoms, number of prior knee surgeries, and postoperative rehabilitation. 26 , 39 , 40 The use of MACI is not recommended in patients over 65 years of age who have generalized degeneration of the cartilage or osteoarthritis. In this study, we only recruited patients aged 14–60 years.…”

Section: Discussionmentioning

confidence: 99%

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Zhang¹,

Zhong²,

Ji³

et al. 2014

DDDT

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Articular cartilage injury is the most common type of damage seen in clinical orthopedic practice. The matrix-induced autologous chondrocyte implant (MACI) was developed to repair articular cartilage with an advance on the autologous chondrocyte implant procedure. This study aimed to evaluate whether MACI is a safe and efficacious cartilage repair treatment for patients with knee cartilage lesions. The primary outcomes were the Knee Injury and Osteoarthritis Outcome Score (KOOS) domains and magnetic resonance imaging (MRI) results, compared between baseline and postoperative months 3, 6, 12, and 24. A total of 15 patients (20 knees), with an average age of 33.9 years, had a mean defect size of 4.01 cm2. By 6-month follow-up, KOOS results demonstrated significant improvements in symptoms and knee-related quality of life. MRI showed significant improvements in four individual graft scoring parameters at 24 months postoperatively. At 24 months, 90% of MACI grafts had filled completely and 10% had good-to-excellent filling of the chondral defect. Most (95%) of the MACI grafts were isointense and 5% were slightly hyperintense. Histologic evaluation at 15 and 24 months showed predominantly hyaline cartilage in newly generated tissue. There were no postoperative complications in any patients and no adverse events related to the MACI operation. This 2-year study has confirmed that MACI is safe and effective with the advantages of a simple technique and significant clinical improvements. Further functional and mechanistic studies with longer follow-up are needed to validate the efficacy and safety of MACI in patients with articular cartilage injuries.

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Section: Discussionmentioning

confidence: 99%

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Zhang¹,

Zhong²,

Ji³

et al. 2014

DDDT

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“…Excellent reviews on cellular techniques such as ACI (autologous chondrocyte implantation), chondrospheres and MACI (Matrix-induced autologous chondrocyte implantation) are available 24, 25 . Here we focus on cellular components of hierarchical osteochondral (OC) grafts.…”

Section: Biomimetic System Component I: Cellsmentioning

confidence: 99%

Challenges in engineering osteochondral tissue grafts with hierarchical structures

Gadjanski

Vunjak-Novakovic

2015

Expert Opinion on Biological Therapy

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Introduction A major hurdle in treating osteochondral (OC) defects are the different healing abilities of two types of tissues involved - articular cartilage and subchondral bone. Biomimetic approaches to OC-construct-engineering, based on recapitulation of biological principles of tissue development and regeneration, have potential for providing new treatments and advancing fundamental studies of OC tissue repair. Areas covered This review on state of the art in hierarchical OC tissue graft engineering is focused on tissue engineering approaches designed to recapitulate the native milieu of cartilage and bone development. These biomimetic systems are discussed with relevance to bioreactor cultivation of clinically sized, anatomically shaped human cartilage/bone constructs with physiologic stratification and mechanical properties. The utility of engineered OC tissue constructs is evaluated for their use as grafts in regenerative medicine, and as high-fidelity models in biological research. Expert opinion A major challenge in engineering OC tissues is to generate a functionally integrated stratified cartilage-bone structure starting from one single population of mesenchymal cells, while incorporating perfusable vasculature into the bone, and in bone-cartilage interface. To this end, new generations of advanced scaffolds and bioreactors, implementation of mechanical loading regimens, and harnessing of inflammatory responses of the host will likely drive the further progress.

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“…It is essential to confi rm that the patient's symptoms are attributable to the chondral lesion [ 8 ]. Pain is typically localised to the joint line and may be associated with an effusion.…”

Section: Assessment Of Injury History and Examinationmentioning

confidence: 99%

“…Long-leg alignment views may also be necessary to identify abnormal alignment of the tibiofemoral joint [ 8 ]. Magnetic resonance imaging (MRI) is the gold standard for identifi cation of chondral injuries and should form part of the initial radiological assessment [ 9 ].…”

Section: Radiological Evaluationmentioning

confidence: 99%

Matrix-Induced Autologous Chondrocyte Implantation

Johnston

Faimali

Gikas

et al. 2014

Techniques in Cartilage Repair Surgery

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New and Emerging Techniques in Cartilage Repair: Matrix-Induced Autologous Chondrocyte Implantation

Cited by 43 publications

References 47 publications

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Matrix-induced autologous chondrocyte implantation for the treatment of chondral defects of the knees in Chinese patients

Challenges in engineering osteochondral tissue grafts with hierarchical structures

Matrix-Induced Autologous Chondrocyte Implantation

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