New amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp

Ruiz, Helga K.; Serrano, Dolores R.; Dea-Ayuela, María Auxiliadora; Bilbao-Ramos, Pablo; Bolás‐Fernández, F.; Torrado, J. J.; Molero, Gloria

doi:10.1016/j.ijpharm.2014.07.004

Cited by 65 publications

(55 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cyclodextrins are known to act synergistically to improve the potency of a range of antifungal compounds (e.g., ref. 7). In this study, we show that living organisms use the synergistic application of cyclodextrins and lipopeptides to produce an antifungal effect.…”

Section: Significancementioning

confidence: 71%

“…β-cyclodextrins produced by the same Anabaena strains could target fungal ergosterolcontaining membranes by extracting ergosterol from the membrane, thereby changing the native function of the membrane. Commercially available amphotericin B and cyclodextrins used together showed an increase of 60% in antifungal activity compared with amphotericin B alone (7). Another example of improved efficacy in the treatment of oral candidosis in patients with AIDS comes from the use of commercially available itraconazole in complex with cyclodextrins (28).…”

Section: Significancementioning

confidence: 99%

“…Cyclodextrins are capable of forming inclusion complexes with different compounds, thereby improving their solubility, reactivity, and stability, a property that has been widely exploited in the pharmaceutical industry (4)(5)(6). Cyclodextrins are used in the pharmaceutical industry to improve drug delivery and the encapsulation of antibiotics for the prevention and treatment of infections (1,4,7).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria

Shishido

Jokela

Kolehmainen

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Cyclodextrins are cyclic oligosaccharides widely used in the pharmaceutical industry to improve drug delivery and to increase the solubility of hydrophobic compounds. Anabaenolysins are lipopeptides produced by cyanobacteria with potent lytic activity in cholesterolcontaining membranes. Here, we identified the 23-to 24-kb gene clusters responsible for the production of the lipopeptide anabaenolysin. The hybrid nonribosomal peptide synthetase and polyketide synthase biosynthetic gene cluster is encoded in the genomes of three anabaenolysin-producing strains of Anabaena. We detected previously unidentified strains producing known anabaenolysins A and B and discovered the production of new variants of anabaenolysins C and D. Bioassays demonstrated that anabaenolysins have weak antifungal activity against Candida albicans. Surprisingly, addition of the hydrophilic fraction of the whole-cell extracts increased the antifungal activity of the hydrophobic anabaenolysins. The fraction contained compounds identified by NMR as α-, β-, and γ-cyclodextrins, which undergo acetylation. Cyclodextrins have been used for decades to improve the solubility and bioavailability of many drugs including antifungal compounds. This study shows a natural example of cyclodextrins improving the solubility and efficacy of an antifungal compound in an ancient lineage of photosynthetic bacteria.natural products | bioactive compounds | hydroxyamino fatty acid | NRPS | PKS

show abstract

Section: Significancementioning

confidence: 71%

Section: Significancementioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria

Shishido

Jokela

Kolehmainen

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Hamster [68] HPβ-, RMβ-CD Efficacy Melarsoprol Oral T. brucei brucei Mouse [89] β-CD Bitter taste masking Artemether Oral ND Human [40]. § Data obtained from [38].…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Cyclodextrin Complexes for Treatment Improvement in Infectious Diseases

Imperiale

Sosnik

2015

Nanomedicine (Lond.)

View full text Add to dashboard Cite

Infectious diseases are a heterogeneous group of maladies that represent a serious burden to healthcare systems worldwide. Most of the available antimicrobial drugs display poor biopharmaceutical properties that compromise their effectiveness. Cyclodextrins (CDs) are cyclic oligosaccharides of glucopyranose formed by a variable number of repeating units that combine a hydrophilic surface with a hydrophobic cavity. The production of drug/CD complexes has become one of the most extensively investigated technology approaches to improve the stability, solubility, dissolution rate and bioavailability of drugs. The present work overviews the applications of CDs for the formulation of anti-infective agents along with the most relevant administration routes. Finally, an update on the complexes with CDs available on the market to treat infectious diseases is presented.

show abstract

“…Despite the suggestion by the authors that the AmB-CD could be employed in catheters and prosthesis to prevent fungal infections of bloodstream, a requirement for further toxicological and clinical studies is warranted before its use in humans. 207 In another study, the authors elaborated gold surfaces functionalized to anidulafungin (ANF) or thymol (THY) with HP-β-CD and randomly methylated β-CD (RAMEB) complexes. Both antifungal complexes displayed similar anti-biofilm action.…”

mentioning

confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

213

View full text Add to dashboard Cite

Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

show abstract

New amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp

Cited by 65 publications

References 33 publications

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria

Antifungal activity improved by coproduction of cyclodextrins and anabaenolysins in Cyanobacteria

Cyclodextrin Complexes for Treatment Improvement in Infectious Diseases

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Contact Info

Product

Resources

About