New amino acid esters of salicylanilides active against MDR-TB and other microbes

In VitroAntibacterial and Antifungal Activity of Salicylanilide Benzoates

“…Salicylanilides were prepared by the procedure described previously [7]. The esters were prepared from salicylanilides by using benzoic acid and N , N ′-dicyclohexylcarbodiimide as dehydrating and condensation agent (e.g., [7]).…”

“…Various salicylanilide (2-hydroxy- N -phenylbenzamide) esters have displayed good antibacterial and antifungal activities, especially against Gram-positive strains [5–7]. Recently salicylanilides were described besides an excellent antibacterial acting against both drug-sensitive and methicillin-resistant S. aureus inhibition activity towards bacterial transglycosylase, an enzyme necessary for the formation of the cell wall [8].…”

Salicylanilide diethyl phosphates as cholinesterases inhibitors

“…They were obtained by a quite simple procedure (Scheme 1). First, salicylanilides were prepared by the reaction of appropriate salicylic acids with anilines in the presence of phosphorus trichloride under microwave irradiation [14]. In the next step, salicylanilide triethyl ammonium salts generated in situ were esterified with diethyl chlorophosphate at ambient temperature [23].…”

“…Salicylanilide-like derivatives have exhibited a wide range of interesting biological activities [14][15][16][17][18][19][20]. Previously, two groups of salicylanilide derivatives have been reported as cholinesterases inhibitors -salicylanilide N-alkyl carbamates [21] and, more importantly, O,O-diethyl thiophosphates (phosphorothioates) which were described as potent inhibitors of both AChE and BChE with IC 50 values in the micromolar range [22].…”

Antiviral Activity of Substituted Salicylanilides - A Review

“…Importantly, salicylanilide derivatives are known for their long time ago discovered activity against different bacteria, fungi and human and veterinarian parasites [1]. They are still investigated and modified for antimycobacterial activity against typical, atypical and resistant mycobacteria [19][20][21][22][23][24][25][26], different fungal strains [23][24][26][27][28][29] or bacteria, especially Gram-positive [26,28,[30][31][32][33][34][35][36][37].…”