New alterations at potentially regulated regions of the Glial Derived Neurotrophic Factor gene in bipolar disorder

Safari, Roghaiyeh; Tunca, Zeliha; Özerdem, Ayşegül; Ceylan, Deniz; Yazıcıoğlu, Çiğdem Eresen; Sakızlı, Meral

doi:10.1016/j.jad.2014.06.002

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…The diagnosis of BP was con¯rmed by two psychiatrists through structured interview for axis I disorders for the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (SCID-I) as described already (Safari et al, 2014). A total of 56 healthy volunteers among the residents, faculty or sta® of the university hospital, who consented to participate, were included in the study.…”

Section: Subjectsmentioning

confidence: 99%

“…The quality and quantity of DNA samples were measured with Pico drop as described in previous studies (Safari et al, 2014). PCR primers were designed by primer 3.4 software (Rozen & Skaletsky, 2000) and manufactured by DNAlab.…”

Section: Genetic Analysismentioning

confidence: 99%

“…Primer sequences, ampli¯cation conditions and PCR components are shown in Table 2. We used PCR components as described already (Safari et al, 2014). The PCR reactions were performed on a 48 well, Techne thermal Cycler in PCR tubes.…”

Section: Genetic Analysismentioning

confidence: 99%

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Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca2+ uptake 1 gene in bipolar disorder patients

Safari¹,

Salimi

Tunca

et al. 2016

J. Integr. Neurosci.

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Calcium signaling is important for synaptic plasticity, generation of brain rhythms, regulating neuronal excitability, data processing and cognition. Impairment in calcium homeostasis contributed to the development of psychiatric disorders such as bipolar disorder (BP). MCU is the most important calcium transporter in mitochondria inner membrane responsible for influx of Ca[Formula: see text]. MICU1 is linked with MCU and has two canonical EF hands that are vital for its activity and regulates MCU-mediated Ca[Formula: see text] influx. In the current study, we aimed to investigate the role of genetic alteration of EF hand calcium binding motifs of MICU1 on the development of BP. We examined patients with BP, first degree relatives of these patients and healthy volunteers for mutations and polymorphisms in EF hand calcium binding motifs of MICU1. The result showed no SNP/mutation in BP patients, in healthy subjects and in first degree relatives. Additionally, alignment of the EF hand calcium binding regions among species (Gallus-gallus, Canis-lupus-familiaris, Bos-taurus, Mus-musculus, Rattus-norvegicus, Pan-troglodytes, Homosapiens and Danio-rerio) showed exactly the same amino acids (DLNGDGEVDMEE and DCDGNGELSNKE) except in one of the calcium binding domain of Danio-rerio that there was only one difference; leucine instead of Methionine. Our results showed that the SNP on EF-hand Ca[Formula: see text] binding domains of MICU1 gene had no effect in phenotypic characters of BP patients.

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Section: Subjectsmentioning

confidence: 99%

Section: Genetic Analysismentioning

confidence: 99%

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Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca2+ uptake 1 gene in bipolar disorder patients

Safari¹,

Salimi

Tunca

et al. 2016

J. Integr. Neurosci.

Self Cite

View full text Add to dashboard Cite

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The Age of Onset of Bipolar Disorders

Dagani¹,

Baldessarini

Signorini³

et al. 2018

Age of Onset of Mental Disorders

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Glial cell-derived neurotrophic factor gene polymorphisms affect severity and functionality of bipolar disorder

Safari

Tunca

Özerdem

et al. 2018

JIN

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Glial cell-derived neurotrophic factor and other neurotrophins have important role in the development of mental disorders. Here, we aimed to assess the effects of Single nucleotide polymorphisms at potentially regulated regions of GDNF on severity and functionality of bipolar disorder and GDNF serum levels in bipolar disorder patients and healthy volunteers. Severity and functionality of bipolar disorder were evaluated using the Clinical Global Impression and Global Assessment of Functioning scales in sixty-six bipolar disorder patients. The GDNF serum levels obtained from bipolar disorder patients and healthy volunteers who had been already reported SNPs information by our group. GAF scales were lower and GDNF serum levels were higher in Bipolar disorder patients with T/A genotype at 5:37812784 and 5:37812782 compared to patients with T/T genotype. There were significant difference in severity and functionality scores, but not in GDNF serum levels, between patients with G/G and G/A genotype of rs62360370 G > A SNP.rs2075680 C > A and rs79669773 T > C SNPs had no effect on bipolar disorder severity and functionality scores and GDNF serum levels. The results suggest that some SNPs of GDNF have potential association with severity and functionality of bipolar disorder. In addition, except two SNPs, none of GDNF SNPs had association with GDNF serum levels.

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New alterations at potentially regulated regions of the Glial Derived Neurotrophic Factor gene in bipolar disorder

Cited by 4 publications

References 47 publications

Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca2+ uptake 1 gene in bipolar disorder patients

Mutation/SNP analysis in EF-hand calcium binding domain of mitochondrial Ca2+ uptake 1 gene in bipolar disorder patients

The Age of Onset of Bipolar Disorders

Glial cell-derived neurotrophic factor gene polymorphisms affect severity and functionality of bipolar disorder

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