New Alkaloids from the Leaves of<i>Cephaelis correae</i>

Achenbach, Hans; Lottes, M.; Waibel, Reiner; Karikas, George A.; Gupta, Michèle

doi:10.1055/s-2006-959849

Cited by 2 publications

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“…Of some 200 species of Cephdelis occurring throughout the tropics, 21 occur in Panama, 10 of these being endemic and several used by the Guaymi Indians of Panama for dizziness, hallucinations, dementia, and rubella (1). Phytochemical studies on only two of the Panamanian species: Cephaelis correae and Cephdelis dichroa have recently been reported (2,3) Cephdelis axillaris Sw. is a shrub of up to 1.5m, growing in the Province of Chiriqui, Panama. This plant is widespread in the tropics, extending from Mexico, through Central America, to Colombia and Venezuela.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and Phytochemical Studies ofCephäelis axillaris

Martı́n

Gupta²,

Urbina³

et al. 1994

Planta Med

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also occurs in the West Indies. Because of the chemotaxonomic and ethnomedical importance of Cephäelis species and due to positive results of testing for the presence of indole alkaloids in this plant, we decided to investigate C. axillaris, as no previous studies had been reported on this species. Materials and Methods General experimental procedures 1D-and 2D-NMR spectra were performed at 200 (250) MHz for 1H and 50MHz for 13C on a Bruker WP 200 SY (AC-250) spectrometer, in DMSO-d6 solution with TMS as internal standard. IR and LV spectra were run in CHC13 solutions.

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Section: Introductionmentioning

confidence: 99%

Pharmacological and Phytochemical Studies ofCephäelis axillaris

Martı́n

Gupta²,

Urbina³

et al. 1994

Planta Med

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Metabolomics analysis reveals enhanced salt tolerance in maize through exogenous Valine-Threonine-Isoleucine-Aspartic acid application

Wu,

Liang,

Zhang

et al. 2024

Front. Plant Sci.

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Salt stress is a well-known abiotic constraint that hampers crop productivity, affecting more than 424 million hectares of topsoil worldwide. Applying plant growth regulators externally has proven effective in enhancing crop resilience to salt stress. Previous metabolomics studies revealed an accumulation of Valine-Threonine-Isoleucine-Aspartic acid (VTID) in salt-stressed maize seedlings, suggesting its potential to assist maize adaptation to salt stress. To explore the effectiveness of VTID in enhancing salt tolerance in maize, 10 nM VTID was applied to salt-stressed maize seedlings. The results showed a remarkable 152.29% increase in plant height and a 122.40% increase in fresh weight compared to salt-stressed seedlings. Moreover, the addition of VTID enhanced the activity of antioxidant enzymes, specifically superoxide dismutase (SOD) and catalase (CAT), while reducing the level of malondialdehyde (MDA), a marker of oxidative stress. Additionally, VTID supplementation resulted in a significant increase in osmoregulatory substances such as proline. Metabolomic analysis revealed substantial changes in the metabolite profile of maize seedlings when treated with VTID during salt stress. Differential metabolites (DMs) analysis revealed that the identified DMs primarily belonged to lipids and lipid-like molecules. The receiver operating characteristic curve and linear regression analysis determined a correlation between isodolichantoside and the height of maize seedlings under salt-stress conditions. In conclusion, these findings validate that VTID effectively regulates tolerance in maize seedlings and offers valuable insights into the potential of short peptides for mitigating salt stress.

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New Alkaloids from the Leaves ofCephaelis correae

Abstract: The El-mass spectrum showed a molecular ion peak M at m/z 521, which was confirmed by positive and negative FAB-MS. From the high-resolution mass spectrum the molecular formula could be deduced as C28H35N505. The 1H-NMR showed characteristic signals for an indole moiety:

Cited by 2 publications

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Pharmacological and Phytochemical Studies ofCephäelis axillaris

Pharmacological and Phytochemical Studies ofCephäelis axillaris

Metabolomics analysis reveals enhanced salt tolerance in maize through exogenous Valine-Threonine-Isoleucine-Aspartic acid application

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