“…The second part of the work of this thesis is the COW, a software suite that covers the whole workflow of TEM image processing from micrographs to 3D structures. Work on the COW has been ongoing since 2008 [26,107,84,117]. It offers high degrees of automation but also a highly flexible graphical programming interface with a large variety of algorithmic modules that can be chained together to customize the workflow and solve problems specific to the sample of interest.…”