Abstract:Introduction: Prevention of cardiac remodeling induced by myocardial infarction (MI) is of great importance because it is one of the factors for the development of heart failure (HF). Thus, LASSBio-1027 was tested in acute model of MI due to its vasodilatory and anti-proliferative profile through the activation of adenosine A 2A and A 3 receptors.Methods: Protocols were approved by Animal Care and Use Committee at Universidade Federal do Rio de Janeiro. MI was induced in male Wistar rats (180-200 g) which were… Show more
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