New adsorptive square wave method for trace determination of prilocain in the flow injection system by a fast fourier analysis

Norouzi, Parviz; Dinarvand, Rassoul; Eshraghi, Mohammad Hasan; Zamani, Hassan Ali

doi:10.1134/s1023193510090053

Cited by 8 publications

(2 citation statements)

References 29 publications

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“…The literature shows that capillary electrophoresis 3 , HPLC with different detection [8][9][10][11][12][13][14][15][16][17][18][19] , Liquid chromatography-tandem mass spectrometry 20 , sequential injection chromatography with Franz cell 21 and adsorptive square wave method 22 have been reported for determination of alone prilocaine and the binary mixture with other local anesthetics of prilocaine in biological samples (plasma and serum) and pharmaceutical preparations. Besides the determination of prilocaine and the mixtures with other local anesthetics of prilocaine in biological materials (plasma and urine) have been done with gas chromatographymass spectrometry method 23,24 and gas chromatography method [25][26][27][28][29][30][31] .…”

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confidence: 99%

Determination of Prilocaine HCl in Pharmaceutical Preparations by GC-MS Method

Atila¹,

Kadıoğlu²

2014

Asian J. Chem.

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To our best of knowledge, no GC-MS method for the analysis of prilocaine HCl in any pharmaceutical preparations was available in the literature. The development and validated an effective method for analysis of drugs in pharmaceutical preparations and biological samples for understanding the therapeutic and toxic effects of drugs is critically important. The aim of the present work is to develop and validate a new GC-MS method for determination of alone prilocaine HCl with a simple sample preparation without derivatization in pharmaceutical preparations using internal standard methodology. EXPERIMENTALPrilocaine HCl reference substance and lidocaine HCl used as internal standard (Fig. 1-B, IS) was a kindly supplied by Novartis Pharmaceutical Industry (Ankara, Turkey) and Doping Control Center of Hacettepe University (Ankara, Turkey). The high-purity all other reagents were purchased from Merck (Germany). All gases were supplied by Havas (Ankara, Turkey)Pharmaceutical preparations: The following pharmaceutical preparations of prilocaine HCl were obtained from local sources in Erzurum (Turkey):Emla ® cream (5 % cream, Astra Zeneca A.S., Turkey) containing 25 mg prilocaine HCl, 25 mg lidocaine HCl, 55 mg poloxamer188 and 155 mg poloxomer 407.Citanest ® injection (2 % flacon, Astra Zeneca A.S., Turkey) containing prilocaine HCl 400 mg/20 mL, methyl parahydroxybenzoate and sodium chloride.

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Section: Introductionmentioning

confidence: 99%

Determination of Prilocaine HCl in Pharmaceutical Preparations by GC-MS Method

Atila¹,

Kadıoğlu²

2014

Asian J. Chem.

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“…Several methods have been reported for determination of prilocaine HCl in biological samples and pharmaceutical formulations including the capillary electrophoresis method [3], HPLC with different detection [5,[6][7][8][9][10][11][12][13][14][15][16], liquid chromatography-tandem mass spectrometry [17], sequential injection chromato-graphy with Franz cell [18], adsorptive square wave method [19] and spectrophotometry method [20]. In addition, the determination of mixtures with other local anesthetics of prilocaine HCl in biological samples have been done with GC-MS [21,22] and GC methods [23][24][25][26][27][28][29].…”

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confidence: 99%

Determination of prilocaine HCl in bulk drug and pharmaceutical formulation by GC-NPD method

Atila

Kadıoğlu

2013

CI&CEQ

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The novel analytical method was developed and validated for determination of prilocaine HCl in bulk drug and pharmaceutical formulation by gas chromatography-nitrogen phosphorus detection (GC-NPD). The chromatographic separation was performed using a HP-5MS column. The calibration curve was linear over the concentration range of 40-1000 ng ml-1 with a correlation coefficient of 0.9998. The limits of detection (LOD) and quantification (LOQ) of method were 10 ng ml-1 and 35 ng ml-1, respectively. The within-day and between-day precision, expressed as the percent relative standard deviation (RSD%) was less than 5.0%, and accuracy (percent relative error) was better than 4.0%. The developed method can be directly and easily applied for determination of prilocaine HCl in bulk drug and pharmaceutical formulation using internal standard methodology

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