New acylides: synthesis of 3-<i>O</i>-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives

Pandey, Daya Shankar; Haq, W.; Katti, S. B.

doi:10.3762/bjoc.4.14

Cited by 4 publications

(2 citation statements)

References 13 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After acylides were identified as a promising class of macrolide antibiotics, new acylides 3-O-[ -(4-oxo-2-arylthiazolidin-3-yl)butyryl]erythromycin A derivatives (4) were obtained by Deepa Pandey [4]. As a result, they were very active against erythromycin-resistant strains comparable to telithromycin.…”

Section: -O-descladinosyl Derivativesmentioning

confidence: 99%

Various Novel Erythromycin Derivatives Obtained by Different Modifications: Recent Advance in Macrolide Antibiotics

2010

MRMC

View full text Add to dashboard Cite

The rapid emergence of drug resistance intensified the search for new antimicrobial agents, leading to lots of novel derivatives obtained from 14- and 15-membered macrolides by chemical modifications. Many of them exhibited enhanced antibacterial activity and expanded antibacterial spectrum. Especially some of them were found to be potent for the treatment of multi-drug-resistant bacterial infections. Besides, the other biological effects of macrolide derivatives were also found. In this article, we reviewed the recent advance in the novel macrolide derivatives designed by different structural modifications on erythronolide skeleton, cladinose and desosamine in the structures.

show abstract

Section: -O-descladinosyl Derivativesmentioning

confidence: 99%

Various Novel Erythromycin Derivatives Obtained by Different Modifications: Recent Advance in Macrolide Antibiotics

2010

MRMC

View full text Add to dashboard Cite

show abstract

“…Oral medication can also be prescribed for asthma in the form of leukotriene receptor antagonists, theophyllines or oral glucocorticocoids [1,2]. Reproduced from [134]…”

Section: Reduced Corticosteroid Sensitivity In Smokers With Asthmamentioning

confidence: 99%

Effects Of Azithromycin On Asthma Control, Airway Inflammation And Bacterial Colonisation In Smokers With Asthma: A Randomized Controlled Trial

Cameron

2012

C22. Asthma Therapy

View full text Add to dashboard Cite

show abstract

Long‐term macrolide treatment of chronic inflammatory airway diseases: risks, benefits and future developments

Cameron

McSharry

Chaudhuri

et al. 2012

Clin Experimental Allergy

View full text Add to dashboard Cite

Macrolide antibiotics were discovered over 50 years ago and following their use as antimicrobials it became apparent that this group of antibiotics also possessed anti-inflammatory properties. Subsequent clinical trials showed benefits of macrolides as long-term adjuncts in the treatment of a spectrum of chronic inflammatory respiratory diseases, particularly diffuse panbronchiolitis, cystic fibrosis, post-transplant bronchiolitis obliterans and more recently chronic obstructive pulmonary disease (COPD). The evidence for efficacy of macrolides in the long-term treatment of chronic asthma and bronchiectasis is less well established. The mechanism(s) of action of macrolides in the treatment of these diseases remains unexplained, but may be due to their antibacterial and/or anti-inflammatory actions, which include reductions in interleukin-8 production, neutrophil migration and/or function. Macrolides have additional potentially beneficial properties including anti-viral actions and an ability to restore corticosteroid sensitivity. The increased prescribing of macrolides for long-term treatment could result in the development of microbial resistance and adverse drug effects. New macrolides have been developed which do not possess any antimicrobial activity and hence lack the ability to produce microbial resistance, but which still retain immunomodulatory effects. Potentially novel macrolides may overcome a significant barrier to the use of this type of drug for the long-term treatment of chronic inflammatory airway diseases.

show abstract

New acylides: synthesis of 3-O-[γ-(4-oxo-2-aryl-thiazolidin-3-yl)butyryl]erythromycin A derivatives

Cited by 4 publications

References 13 publications

Various Novel Erythromycin Derivatives Obtained by Different Modifications: Recent Advance in Macrolide Antibiotics

Various Novel Erythromycin Derivatives Obtained by Different Modifications: Recent Advance in Macrolide Antibiotics

Effects Of Azithromycin On Asthma Control, Airway Inflammation And Bacterial Colonisation In Smokers With Asthma: A Randomized Controlled Trial

Long‐term macrolide treatment of chronic inflammatory airway diseases: risks, benefits and future developments

Contact Info

Product

Resources

About