New Acetogenins from the Seeds of <i>Annona coriacea</i>

Alves, Thayana da C.; Gonçalves, Mariele Rondon Santos; Correia, Francyne C. S.; Silva, Virgínia C. da; Sousa, Paulo Teixeira de; Carvalho, Mário Geraldo de; Braz-Filho, Raimundo; Dall’Oglio, Evandro Luiz

doi:10.1002/hlca.201400034

Cited by 9 publications

(1 citation statement)

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“…The Annonaceae family has a wide variety of chemical compounds [23,24], and acetogenins are secondary metabolites considered chemotaxonomic markers. Uvaricin [25] was the first cytotoxic isolated acetogenin and opened a new field of research.…”

Section: Discussionmentioning

confidence: 99%

Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

et al. 2023

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Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search for more effective and specific treatments is essential, making plants a promising source for elucidating new anti-glioblastoma compounds. Accordingly, this study investigated the effects of four fractions of hexane and ethyl acetate extract of Annona coriacea Mart., enriched with acetogenins, against GBM cell lines. All four fractions were selectively cytotoxic to GBM cells when compared to TMZ. Moreover, A. coriacea fractions delayed cell migration; reduced cytoplasmic projections, the metalloproteinase 2 (MMP-2) activity; and induced morphological changes characteristic of necroptosis, possibly correlated with the increase in receptor-interacting protein kinase 1 and 3 (RIP-1 and RIP-3), apoptosis-inducing factor (AIF), and the non-activation of cleaved caspase 8. The present findings reinforce that fractions of A. coriacea Mart. should be considered for more studies focusing treatment of GBM.

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Section: Discussionmentioning

confidence: 99%

Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

et al. 2023

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Effects of Acetogenins from Annona coriacea on the in Vitro Reactions of Photosynthesis

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Junqueira

et al. 2020

Chemistry & Biodiversity

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Our search for candidates for photosynthesis inhibitors is allowing us to report the effect of two acetogenins identified in Annona coriacea Mart. leaves, ACGÀ A and ACGÀ B, a non-adjacent bis-THF and a mono-THF types, respectively. This is an important class of natural products which presents biological properties such as anticancer, neurotoxic, larvicidal and insecticidal. However, this is only the second report associated to its herbicidal activity. Their mechanisms of action on the light reactions of the photosynthesis were elucidated by polarographic techniques. Compounds inhibited the noncyclic electron transport on basal, phosphorylating, and uncoupled conditions from H 2 O to methyl viologen (MV); therefore, they act as Hill reaction inhibitors. Studies on fluorescence of chlorophyll a (ChL a) indicated that they inhibited the acceptor side of PSII between P680 and PQ-pool, exactly as the commercial herbicide DCMU does.

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