New 3D and 2D supramolecular heteroleptic palladium(II) dithiocarbamates as potent anticancer agents

Khan, Shahan Zeb; Amir, Muhammad Kashif; Abbasi, Rashda; Tahir, Muhammad Nawaz; Rehman, Zia ur

doi:10.1080/00958972.2016.1225198

Cited by 18 publications

(3 citation statements)

References 24 publications

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“…Dithiocarbamate compounds can be used as radiochemotherapeutic treatments to target tumors [33][34][35][36][37]. One of the important metal-chelating antioxidants is dithiocarbamate molecules and their derivatives [38].…”

Section: ■ Dithiocarbamatementioning

confidence: 99%

Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

et al. 2022

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The importance of essential metal ions and their metal complexes in the creation of prospective medical therapies has long been recognized. In chemistry, molecular biology, and medicinal fields; the interaction of metal complexes with DNA has been a subject of study. The dithiocarbamate essential metal complex is described extensively in the literature for its various benefits and advantages. With proper use of ligands, it is proven to increase the cytotoxic activity of metal complexes against cancer cells. Some researches have shown significant progress regarding the biological activities of the dithiocarbamate essential metal complex as antimicrobial, antioxidant, and anticancer agents. Metal complexes form complexes with dithiocarbamate ligands with unique structural variations. In this study, we presented an overview of the cytotoxic effects of some dithiocarbamate essential metal complexes on cancer cells, as well as fresh approaches to the design of essential metal-based therapeutics containing dithiocarbamate and molecular targets in cancer therapy. This review may provide an update on recent developments in the medicinal use of essential metals with dithiocarbamate ligands, carried out to identify recent relevant literature. Finally, we predict that the essential metal complexed with dithiocarbamate can be a new breakthrough in the future development of cancer drugs.

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Section: ■ Dithiocarbamatementioning

confidence: 99%

Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

et al. 2022

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“…Figure 14: The Ni (II) complex existing as both cis and trans isomers [75] Palladium Compounds as Antimicrobial Agents Palladium as a chemical element with the symbol Pd is a rare metal of the platinum group metals. It is a lustrous silvery white metal with various uses and increasing research as potential therapeutics for various diseases [76][77][78][79]. Palladium has been known to have great potential in medicine because it belongs to the platinum group of metals, and it is a known antagonistic metal in the human body.…”

Section: Nickel Compounds As Antimicrobial Agentsmentioning

confidence: 99%

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2022

J. Med. Chem. Sci.

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“…Polydentate ligands such as polycarboxylic acids or nitrogen‐containing heterocyclic ligands are widely used in the rational design and controlled synthesis of these multifunctional complexes. Recently, N‐heterocyclic carboxylate ligands have attracted considerable attention of chemists and biologists because of their abundant coordination modes and functional properties, as well as hydrogen‐bonding donors and acceptors under solution conditions . It is well known that carboxyl groups can possess potential coordination sites to adopt various coordination modes and the ─ C═ O groups can act as O‐donors .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of Cu (II) and Mn (II) complexes with 1,4‐bis (pyrazol‐1‐yl) terephthalic acid

Gao

Xing

et al. 2018

Applied Organom Chemis

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Two novel complexes, [Cu (L)(H2O)]⋅H2O (1) and [Mn (H2O)6] ⋅L ⋅H2O (2) (L = 1,4‐bis (pyrazol‐1‐yl) terephthalic acid), were synthesized under hydrothermal conditions. They were characterized using elemental analysis, infrared spectroscopy and single‐crystal X‐ray diffraction. Intramolecular weak interactions, such as hydrogen bonds, and intermolecular interactions play important roles in the construction of the complexes. The interaction of these complexes with fish sperm DNA (FS‐DNA) was monitored and binding constants were determined using UV–visible spectroscopy, which revealed their ability to bind to FS‐DNA, with binding constants for the two complexes of 1.88 × 104 M−1 (1) and 1.06 × 104 M−1 (2). Viscosity experiments further demonstrated the binding of the complexes to DNA. The complexes were further studied using gel electrophoresis assay with supercoiled plasmid pBR322 DNA. In addition, anticancer activities of the metal complexes investigated through MTT assays in vitro indicated good cytotoxic activity against cancer cell lines. Flow cytometry and apoptosis experiments showed that these complexes induced apoptosis of two different cancer cell lines (HeLa and KB cells), demonstrating a significant cancer cell inhibitory rate. Finally, a further molecular docking technique was employed to confirm the binding of the complexes towards the molecular target DNA.

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New 3D and 2D supramolecular heteroleptic palladium(II) dithiocarbamates as potent anticancer agents

Cited by 18 publications

References 24 publications

Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

Review on Anticancer Activity of Essential Metal Dithiocarbamate Complexes

Untitled

Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of Cu (II) and Mn (II) complexes with 1,4‐bis (pyrazol‐1‐yl) terephthalic acid

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