New 2-functionalized 2H-3,4-dihydro-1,4-benzothiazin-3-ones and their application in the synthesis of spiro heterocycles

Synthesis of small and medium size monocyclic hydroxamic acids (Review)*

“…Thus, ,-unsaturated hydroxamic acids gave 5-CHA. The scheme below shows formation of complex dispiro compound 131 in two steps from benzothiazin-3-one 128 and indole 129 through iminimine tautomer of compound 130 [47]. …”

Chemistry of heterocyclic compounds at the Institute of Organic Chemistry, National Academy of Sciences of Ukraine (Review)

“…2-Chloro-2-ethoxycarbonyl-4H-benzo[1,4]thiazine-3-ones [99], from which various 2-aryl and 2-heteryl derivatives are easily obtained, were synthesized [100][101][102]. …”

Hydrogen-bonded bilayers in 7-benzyl-3-tert-butyl-1-phenyl-4,5,6,7-tetrahydro-1H-spiro[pyrazolo[3,4-b]pyridine-5,2′-indan]-1′,3′-dione

“…Compounds with spiro skeletons not only constitute subunits in numerous alkaloids, but are also templates for drug discovery that have been used as scaffolds for combinatorial libraries (Maier & Wuensch, 2002;Shaabani & Bazgir, 2004;Krasnov & Kartsev, 2005;Lang et al, 2005;Kadutskii & Kozlov, 2006;Kuster et al, 2006;Macleod et al, 2006;Nazarenko et al, 2007). The synthesis of spiro compounds can be achieved using conventional methods and procedures based on three-component one-pot reactions (Marti & Carrei, 2003;Rolandsgard et al, 2005;Arya & Dandia, 2007;Rahimizadeh et al, 2007).…”