New 1,2,4(H)-Triazole Derivatives as Diuretic Agents

Development of a New and Efficient Synthesis Method of 1,2,4-Triazole-5-Thione Derivatives

“…RESULT AND DISCUSSION To achieve 1,2,4-triazoles, derived from 4-hydroxybenzoic acid hydrazide and 4-benzoyl-aminobenzoic acid hydrazide, the one-pot synthesis method of Shah et al (18) was employed. Shah et al (18), reported the synthesis of 3-phenyl-4-n-butyl-5-mercapto-1,2,4-triazole in yield of 50% by using benzoic acid hydrazide as starting compound.…”

“…Shah et al (18), reported the synthesis of 3-phenyl-4-n-butyl-5-mercapto-1,2,4-triazole in yield of 50% by using benzoic acid hydrazide as starting compound. According to the method 1 (18); the ethanolic solutions of the hydrazides, mentioned above, were refluxed with ethyl-, allyl-, cyclohexyl-and phenyl isothiocyanates following 4 hours of heating in 2N NaOH.…”

High-pressure liquid chromatographic analysis for identification of in vitro and in vivo metabolites of 4-phenethyl-5-[4-(1-(2-hydroxyethyl)-3,5-dimethyl-4-pyrazolylazo)phenyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats

“…Intermadiate product 1-[4-(1-(2-hydroxyethyl)-3,5-dimethyl-4-pyrazolylazo)benzoyl]-4-phenethylthiosemicarbazide was prepared in four steps from ethyl 4-aminobenzoat following the reported procedures [18,19]. To the intermediate compound …”

Synthesis, structural and spectroscopic features, and investigation of bioactive nature of a novel organic-inorganic hybrid material 1H-1,2,4-triazole-4-ium trioxonitrate

“…Among these, the 1,2,4-triazole is a basic aromatic heterocycle with molecular formula C 2 H 3 N 3 . 1,2,4-Triazole can be used as a drug precursor because of possessing antibacterial [16][17][18][19][20][21], antifungal, [22,23] antitubercular [24], antimycobacterial [25], anticancer [26,27], diuretic [28,29], and hypoglycemic properties [30]. Antifungal behaviors of triazole based ligands have special importance because they have been used as drugs approved by European Medicines Agency and US FDA for a broad spectrum infections (See Table 1 in Ref.…”