New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAF
V600E
and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study
Wael A. A. Fadaly,
Mohamed T. M. Nemr,
Taha H. Zidan
et al.
Abstract:A new series of bis-triazole
19a-l
was synthesised for the purpose of being hybrid molecules with both anti-inflammatory and anti-cancer activities and assessed for cell cycle arrest, NO release. Compounds
19c
,
19f
,
19h
,
19 l
exhibited COX-2 selectivity indexes in the range of 18.48 to 49.38 compared to celecoxib S.I. = 21.10), inhibit MCF-7 with IC
50
= 9–16 μM compared … Show more
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