Nevus Sebaceous Revisited

Abstract

Nevus sebaceous of Jadassohn is a hamartoma with a combination of abnormalities of the epidermis, hair follicles, and sebaceous and apocrine glands. Herein, we discuss the results of an extensive literature review on the topic of nevus sebaceous with a particular focus on the debate about the necessity for prophylactic excision. We also focus on the documentation of associated malignant tumors that were reported to develop within NS. In addition to reporting the number and types of neoplasms, we documented the recommendations of all authors for therapeutic handling of these nevi.

Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases

“…CO 2 lasers [50] enhance cosmesis, but can only reach the papillary dermis, therefore they are not recommended because of the possibility of malignant degeneration of the remaining cells in the lower dermis [51]. …”

Acantholytic Squamous Cell Carcinoma Arising in a Nevus Sebaceous : A Case Report

“…Tumors observed together included BCC with SCC, sebaceous carcinoma, or KA and SCC with adnexal carcinoma. (3,8,9,10) Our case is very rare variant of SCC (acantholytic) that has not been reported to date arising in nevus sebaceous.…”

Mosaic RASopathies

“…24 The majority of these tumors is benign, comprising mainly trichoblastoma, syringocystadenoma papilliferum and further benign adnexal tumors, but malignant tumors have also been reported. [65][66][67] These tumors derive directly from sebaceous nevus cells, as they were shown to carry the same HRAS mutation as the underlying nevus.…”

“…Histologically they are characterized by abundant sebaceous glands, epidermal hyperplasia and apocrine elements. 24 A peculiar feature of sebaceous nevi is the secondary development of mostly benign tumors in about 25% of lesions during life. These nevi present clinically as hairless, yellow-orange plaques of varying size and shape.…”