Nevus of Ota and intracranial arteriovenous malformation

Massey, E. Wayne; Brannon, W. L.; Moreland, Michael E.

doi:10.1212/wnl.29.12.1625

Cited by 9 publications

(2 citation statements)

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“…Nevus of Ota is usually benign, but also appears to have a low malignant potential [17][18][19][20][21]. Clinically, it is seen in association with different types of vascular conditions like Takayasu's arteritis [26], vascular defect like Klippel-Trénaunay syndrome [27], cerebral malformation [28], Recklinghausen disease and others. Ballooning of posterior fossa producing a step like deformity of the occiput, facial hemiatrophy and pigmentation of the optic disc resulting in slower papillary light reflex have also been noted [5].…”

Section: Discussionmentioning

confidence: 99%

Intermediate-grade meningeal melanocytoma associated with nevus of Ota

et al. 2015

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Meningeal melanocytomas are rare melanin-producing tumors that are often found to be benign. However, a small subset of these tumors can present as intermediate-grade melanocytomas (IGMs) that have histopathological features that are between those of benign melanocytomas and malignant melanomas. IGMs have the potential to recur and metastasize or progress to a more histologically high grade melanoma. Melanocytomas appear to differ from primary and metastatic melanoma by their prolonged clinical course and they appear to have different driver mutations (i.e. mutation of GNAQ gene). The association of a meningeal melanocytoma with nevus of Ota is extremely rare. To our knowledge, there have been only 10 reported cases of synchronous occurrence and only one of the cases involved an IGM. We report the second case of intermediate-grade meningeal melanocytoma that is associated with congenital nevus of Ota. Histopathological work-up confirmed the intermediate grade of the lesion and a driver GNAQ mutation was identified consistent with previous reports.

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Section: Discussionmentioning

confidence: 99%

Intermediate-grade meningeal melanocytoma associated with nevus of Ota

et al. 2015

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“…Similar to nevus of Ota, phakomatosis pigmentovascularis has been reported to be more common in women than men. Systemic involvement is not unusual, and includes ocular and neurologic disorders such as Sturge‐Webber disorder, Klippel‐Trenaunay syndrome, or intracranial arteriovenous malformation 20 . Indeed, in view of the link to neurologic disease, in 1947 Ota et al 21 proposed the name phakomatosis pigmentovascularis.…”

Section: Differential Diagnosis Of Nevus Of Otamentioning

confidence: 99%

Nevus of Ota: Clinical Aspects and Management

Chan¹,

Kono

2003

Skinmed

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Nevus of Ota, or nevus fuscoceruleus ophthalmomaxillaris, is a dermal melanocytic hamartoma that presents as bluish hyperpigmentation along the first or second branches of the trigeminal nerve. Extra-cutaneous involvement has been reported, especially ocular involvement. Nevus of Ota affects between 0.014%-0.034% of the Asian population. Clinical differential diagnoses include facial cafe-au-lait patch, spilus nevus, and acquired bilateral nevus of Ota-like macules. Previous treatment modalities, including cryotherapy and microsurgery, can be associated with scarring. In the last decade, the use of Q-switched lasers has revolutionized the treatment of this condition. This review summarizes the clinical, histologic, and management aspects of this dermal melanocytic hamartoma.

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