Nevus Depigmentosus Systematicus With Partial Yellow Scalp Hair Due to Selective Suppression of Eumelanogenesis

Abstract

We report a Japanese patient with congenital hypomelanosis with a segmental pattern on the left abdomen, whorl-like pattern on the back; mosaic pattern on the chest, right abdomen, and proximal extremities; and with yellow hair on a portion of the scalp. Chemical analysis of the yellow hair revealed decreased eumelanin content, whereas the pheomelanin content was normal.

Hypomelanosis of Ito: No entity, but a cutaneous sign of mosaicism

“…It is just as likely that cases presenting as zosteriform or dermatomal [Metzker et al, 1982] or in a plaque-like pattern or an arrangement in whorls and streaks [Cambazard et al, 1986] or showing skin changes like a systematized nevus depigmentosus [Fukai et al, 1993] should be included into the group of pigmentary mosaicism, although a chromosomal mosaic has not been observed in these cases.…”

Disorders of pigmentation

“…377 Two sisters who presented with guttate and nummular hypomelanosis in a segmental distribution had numerous melanocytes on biopsy but the melanocytes had a decreased number of melanosomes. 379 There are several reports of autologous epidermal grafts being used to treat this condition. 379 There are several reports of autologous epidermal grafts being used to treat this condition.…”

“…379 One study showed a reduction of melanosomes in melanocytes. 379 One study showed a reduction of melanosomes in melanocytes.…”

Focal Scalp Hair Heterochromia in an Infant

“…13 However, a systemic examination in the current case did not reveal evidence of the involvement of any other systems. Moreover, the patient did not have any nutritional deficiencies and the colouration of the affected hair was uniform along the whole shaft.…”