Nevus depigmentosus accompanying nevus comedonicus syndrome

Abstract

Nevus comedonicus is a rare nevoid malformation, characterized by hyperkeratotic comedonal lesions scattered in several parts of the body. Skeletal abnormalities, central nervous system defects and ophtalmological pathologies can accompany the situation and in this condition, it is called nevus comedonicus syndrome. Herein, we present a twenty-eight-year old male patient diagnosed with nevus comedonicus with prepubertal segmentally located inflammatory nodules and comedones. The patient had a medical history of bone cyst and further investigation for nevus comedonicus syndrome revealed cerebral atrophy. Distinguishing property of our case was the accompanying nevus depigmentosus located on the same leg extending to the thigh.

Nevus comedonicus syndrome: A systematic review of the literature

“…Inability to retrieve enough information, redundant publications, and diagnoses judged to be incorrect were reasons for exclusion. Among the latter instances, one case can be nowadays considered Happle‐Tinschert syndrome, 48 while another one was characterized by a flag‐like hypomelanotic nevus as the prominent cutaneous manifestation 49 …”

Cosmetovigilance and Global Approaches

“…En sık rastlanan alerjik reaksiyonların bir bölümü koku maddeleri/esans kaynaklı olarak görülmekte ve bunların bir kısmının bitkisel hammadde kaynaklı olduğu belirtilmektedir. Kozmetik ürünlerde kullanımı doğrultusunda, istenmeyen veya toksik etkilere neden olabilen bitkisel içeriklerin bazı etkileri hipersensitivite reaksiyonu, östrojenik aktivite, alerjik reaksiyon, fotosensitivite, deride yanma, karaciğer toksisitesi, nöromotor disfonksiyon, konjonktival enflamasyon, konvülsiyon, mutajenik etki veya karsinojenik etki olabilmektedir (23)(24)(25)(26).…”