Nevus counting as a risk factor for melanoma: Comparison of self-count with count by physician

Lawson, Deborah D.; Moore, Dan H.; Schneider, J.; Sagebiel, Richard W.

doi:10.1016/s0190-9622(94)70207-1

Cited by 36 publications

(33 citation statements)

References 24 publications

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“…Self-reported numbers of nevi have been found in intermethod reliability studies to have fair to low agreement with dermatologists' nevus counts. [24][25][26] Measurement error could, therefore, explain our inconsistent findings on the relationship between nevus density and strong p53 staining. We expected that melanomas from NSW subjects would have a higher prevalence of p53 staining than those from BC and Ontario, given the higher intensity of ambient UV radiation in NSW; instead, we observed the reverse.…”

Section: Discussionmentioning

confidence: 99%

Etiologic factors associated with p53 immunostaining in cutaneousmalignant melanoma

Purdue

From

Kahn

et al. 2005

Intl Journal of Cancer

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Findings from a case-control study of cutaneous malignant melanoma (CMM) in Queensland, Australia, suggest that melanomas exhibiting p53 immunostaining possess different risk factors from those of other melanomas. To further explore this hypothesis, a case-only analysis of risk factors for p53 immunostaining with anti-p53 MAb DO-7 was undertaken in 523 people diagnosed with CMM in Canada and Australia. Phenotypic factors and past sun exposure were measured using a self-administered questionnaire and telephone interview. The presence of strong p53 staining (>10% of cell nuclei positively stained vs. <1% staining) was positively associated with some indicators of high cumulative sun exposure: lentigo maligna melanoma subtype (OR 5 3.2 vs. superficial spreading subtype), melanoma location on the head and neck (OR 5 2.8 vs. back), histopathologic evidence of solar elastosis (OR 5 2.1) and previous diagnosis of nonmelanoma skin cancer (OR 5 2.4). Strong staining was negatively associated with high nevus density on the back (OR 5 0.2 for >25 nevi vs. 0-3 nevi) and histologic evidence of a coexisting nevus (OR 5 0.3). Other factors associated with strong p53 immunostaining include greater Breslow thickness (OR 5 7.4 for >4.00 vs. <0.76 mm), male sex (OR 5 2.2) and dense freckling (OR 5 6.6 vs. few freckles). Of these, thickness, male sex, dense freckling, low nevus density on the back, histologic subtype and history of nonmelanoma skin cancer appeared to be independently associated with strong p53 staining. Our findings are consistent with the Queensland study in suggesting that variables indicating high accumulated sun exposure are positively associated with p53 staining and that an increased number of nevi is positively associated with its absence; they may reflect etiologic and pathogenetic heterogeneity in melanoma. ' 2005 Wiley-Liss, Inc.Key words: melanoma; p53; risk factor; etiology; epidemiology; case-only study There is indirect evidence for the hypothesis of etiologic heterogeneity in melanoma. Melanomas occurring on habitually sunexposed body sites differ from lesions on intermittently exposed sites in their distribution of histologic subtypes (LMM usually located on head and neck, superficial spreading and nodular melanomas more commonly found on trunk for men and legs for women)1-3 and age at diagnosis (melanomas on face showing a near exponential increase in incidence with age, while incidence on other areas is highest in middle age and falls thereafter).2,4 As well, melanomas on intermittently exposed body sites are commonly associated with a nevus, while this finding is uncommon for melanomas arising on the head and neck.5-8 Case-control studies investigating risk factors for melanomas arising on different body sites have also suggested etiologic heterogeneity. 5,7,[9][10][11][12] In a small case-control study of melanoma, Whiteman et al. 13investigated the etiologic correlates of abnormal tumor cell levels of p53, a nuclear protein that plays a critical role in safeguarding the genome through regulati...

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Section: Discussionmentioning

confidence: 99%

Etiologic factors associated with p53 immunostaining in cutaneousmalignant melanoma

Purdue

From

Kahn

et al. 2005

Intl Journal of Cancer

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“…Individual risk factors play an important part in the development of malignant melanoma [10]. The most important phenotypic risk factors are the number of total body acquired melanocytic nevi and the occurrence of previous epithelial skin cancer [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region

et al. 2005

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“…Lawson et al (1994) focused on the number of large naevi (Z 5 mm) and they observed a better agreement between the patients' and the physicians' counts (79% of agreement). Two main hypotheses can explain this phenomenon.…”

Section: Discussionmentioning

confidence: 95%

Creation and test of a questionnaire for self-assessment of melanoma risk factors

Quéreux

Nguyen²,

Volteau³

et al. 2010

European Journal of Cancer Prevention

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The objective of this study was to create a self-administrated questionnaire for people to enable them to assess their own melanoma risk factors. To test the validity of this questionnaire in a large prospective study, the answers given by the patient were systematically checked by his or her general practitioner. In this prospective study, the choice of questions was based on a review of the literature. The validity of the questionnaire was assessed by testing 1500 consecutive patients attending a consultation with their general practitioner. Considerable variations concerning the prevalence of different melanoma risk factors were noticed in the population: 44.1% had a phototype I or II, 41% had severe sunburn during infancy, 29.9% had freckling tendency, 22% had more than 50 naevi and 1.4% a personal history of melanoma. In total, 45% had more than one melanoma risk factor. The accuracy of the answers given by the patients was assured by the correction given by their general practitioners. The percentage of correct answers given by the patients was 79.9% for the phototype, 90.6% for freckling tendency, 86.6% for the number of naevi, 96.5% for severe sunburn during infancy and 98.1 and 95.8% for personal and familial history of melanoma. This study confirms that individuals with multiple risk factors for melanoma are common among patients consulting their general practitioners. Furthermore, self-screening with the self-assessment questionnaire is easily feasible and is accurate for identifying high-risk individuals. This tool might be useful for carrying out melanoma-targeted screening.

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Nevus counting as a risk factor for melanoma: Comparison of self-count with count by physician

Cited by 36 publications

References 24 publications

Etiologic factors associated with p53 immunostaining in cutaneousmalignant melanoma

Etiologic factors associated with p53 immunostaining in cutaneousmalignant melanoma

Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region

Creation and test of a questionnaire for self-assessment of melanoma risk factors

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