Nevoid Hyperkeratosis of the Areola in Men: Response to Cryotherapy

Nevoid hyperkeratosis of the nipple and/or areola: a report of two cases and a review of the literature

“…Kubota et al 8 . and Mitxelena et al 5 . reported comparable results after using a similar cryotherapy regimen.…”

“…For women, onset usually occurs during the second or third decade of life 4 . In men, the age of onset is much more variable 5 …”

Unilateral Nevoid Hyperkeratosis of the Nipple and Areola Treated Successfully With Carbon Dioxide Laser

“…Desquamation [11] or Yellowish discoloration [12,13] or of the areas may also be present. Occasionally, the lesions appear verrucous [14]. Generally, erythema, induration and discharge do not occur.…”

“…NHNA needs to be differentiated from epidermal naevus, acanthosis nigricans, chronic eczema, atopic eczema, seborrhoic keratosis, Darier's disease, Paget's disease, basal cell carcinoma, dermatophytosis, mycosis fungoide and Bowen's disease [14,17,18]. These diagnoses were ruled out after dermoscopic examination in our patient.…”

“…Various treatment modalities have been reported including topical corticosteroids, topical calcitriol [19], topical and oral retinoids [20], topical keratolytics, surgical techniques including cryotherapy excision [14,15,21,22], radiofrequency ablation [23], and laser [24]. A case of NHNA was successfully treated with carbon dioxide laser [21] and no recurrence was seen.…”